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Table 3 Relationship between expression of CXCL12/CXCR4 and clinicopathological factors

From: CXCL12 expression promotes esophageal squamous cell carcinoma proliferation and worsens the prognosis

  All patients (n = 79) (%)
CXCR4(+) CXCR4(−) p CXCL12(+) CXCL12(−) p
n = 48 (61) n = 31 (39) n = 62 (78) n = 17 (22)
Age, median (range) 58.5 (44–79) 61 (44–74) 0.84c 59 (44–79) 57 (50–70) 0.84c
Gender       
 Male 44 27 0.71a 54 17 0.19a
 Female 4 4 8 0
Histological grade       
 1 11 5 0.69b 12 4 0.90b
 2 34 23 45 12
 3 3 3 5 1
Pathological T       
 Tis 5 5 0.63b 8 2 0.39b
 T1 24 11 28 7
 T2 4 3 7 0
 T3 15 12 19 8
Pathological N       
 Positive 28 18 0.98b 36 10 0.96b
 Negative 20 13 26 7
Lymphatic invasion       
 Absent 13 8 0.90b 17 4 1.00a
 Present 35 23 45 13
Vessel invasion       
 Absent 27 17 0.90b 36 8 0.42b
 Present 21 14 26 9
Recurrence of lymph node metastasis       
 Positive 13 11 0.43b 22 2 0.08a
 Negative 35 20 40 15
Recurrence of distant organ metastasis       
 Positive 13 7 0.65b 17 3 0.54a
 Negative 35 24 45 14
  1. Recurrence of lymph node metastasis or distant organ metastasis means that the initial recurrence region after ESCC resection was lymph node or distant organ
  2. aFisher’s exact probability test
  3. bPearson’s χ-square test
  4. cMann-Whitney U test