Table 2 Univariate and multivariate analysis of clinicopathological factors with serum osteopontin level (A), serum thrombospondin-1 level (B), serum OPN/TSP-1 ratio (C) for overall survival

Osteopontin

Serum level^a

1.95

1.15–3.32

0.01

1.71

1.04–2.82

0.04

Stage

I to IIIA vs IIIB

0.26

0.11–0.61

0.002

0.29

1.04–0.68

0.01

Pleural involvement

Positive vs Negative

1.94

0.93–4.04

0.08

1.11

0.66–1.57

0.73

Lympho-vascular invasion

Positive vs Negative

2.47

1.21–5.03

0.01

1.27

0.56–2.85

0.57

Adjuvant treatment

No vs Yes

1.32

0.63–2.73

0.51

–

–

–

Age

≥65 vs <65

1.61

0.75–3.46

0.24

–

–

–

Gender

Male vs female

1.14

0.56–2.34

0.73

–

–

–

Smoking history

Smoker vs non-smoker

1.14

0.44–2.96

0.80

–

–

–

Thrombospondin-1

Serum level^b

0.15

0.03–0.89

0.04

0.18

0.04–0.87

0.03

Stage

I to IIIA vs IIIB

0.26

0.11–0.61

0.002

0.26

0.11–0.61

0.002

Pleural involvement

Positive vs Negative

1.94

0.93–4.04

0.08

1.13

0.36–1.37

0.69

Lympho-vascular invasion

Positive vs Negative

2.47

1.21–5.03

0.01

1.28

0.58–2.84

0.54

Adjuvant treatment

No vs Yes

1.32

0.63–2.73

0.51

–

–

–

Age

≥65 vs <65

1.61

0.75–3.46

0.24

–

–

–

Gender

Male vs female

1.14

0.56–2.34

0.73

–

–

–

Smoking history

Smoker vs non-smoker

1.14

0.44–2.96

0.80

–

–

–

OPN/TSP1

Ratio^c

1.40

1.08–1.81

0.01

1.31

1.03–1.67

0.03

Stage

I to IIIA vs IIIB

0.26

0.11–0.61

0.002

0.29

0.12–0.68

0.01

Pleural involvement

Positive vs Negative

1.94

0.93–4.04

0.08

0.75

0.24–0.97

0.38

Lympho-vascular invasion

Positive vs Negative

2.47

1.21–5.03

0.01

0.62

0.23–0.89

0.27

Adjuvant treatment

No vs Yes

1.32

0.63–2.73

0.51

–

–

–

Age

≥65 vs <65

1.61

0.75–3.46

0.24

–

–

–

Gender

Male vs female

1.14

0.56–2.34

0.73

–

–

–

Smoking history

Smoker vs non-smoker

1.14

0.44–2.96

0.80

–

–

–