Fig. 4
From: Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma
Immunohistochemistry for HNF1β. a Strong nuclear expression in normal acinar parenchyma and normal ducts (upper part) while the expression is completely lost in a poorly differentiated PDAC (lower part) (Magnification 50x). b IHC shows a lower expression in high-grade dysplasia (upper part) compared to normal duct (arrow) (Magnification 100x). c IHC for HNF1β shows reduced expression in a well to moderately differentiated PDAC compared to a non-neoplastic duct (asterisk) (Magnification 200x). Histograms showing the histoscores corresponding to the left (a) (b) (c). Asterisk on the histogram indicates that the differences with each of the other categories are significant (Mann Whitney test, p < = 0.0294). d Normal pancreas (positive control) showing a strong staining in ducts and in the acinar parenchyma (Magnification 40x)