Fig. 1
From: Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma
Expression heatmap for merged data. a Heatmap for 56 PDAssign genes vs 184 PDAC samples (+13 histologically normal pancreatic tissue samples as “Control” samples in grey). Samples are ordered and clustered by NMF clusters obtained from the NMF clustering of the merged PDAC data. Genes are clustered by hierarchical clustering using Pearson correlation distance (complete linkage). Sample legends show the sample clustering of the published subtypes (for the UCSF and GSE15471 tumors), but also the different predicted clusters from NMF of our 118 PDAC data (k3) and the predicted K-Ras dependency (kras) (see also Additional file 2: Figure S1 and Additional file 3: Figure S2). b Comparison of the predicted subtypes and known subtypes at the sample levels