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Fig. 4 | BMC Cancer

Fig. 4

From: Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine

Fig. 4

Copy number profiles of VHLmut and VHLwt cultures and their matched tissues. Three VHLmut cultures that had reached passage 20 were profiled using Illumina Human Omni2.5–8 SNP arrays. DNA samples obtained from the matching primary tumor and adjacent normal kidney tissue were profiled in parallel, as well as two commercially available cell lines, 786–0 and A-498. For RCC22 and RCC243, the matched VHLwt line was also profiled; RCC364 does not have a matched VHLwt line. Amplifications are shown in blue and deletions in red. VHLwt cell lines do not display any gross genomic alterations, whereas VHLmut cell lines contain alterations matching the tumors from which they were derived. 786–0 and A-498 (bottom), have considerably larger numbers of alterations compared to primary tumors and RCC VHLmut cultures

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BMC Cancer

ISSN: 1471-2407

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