Fig. 4
From: Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models
Cytotoxicity of splenocytes isolated from vaccinated mice. Splenocytes were obtained either from naïve mice or from mice that had been previously vaccinated (either B16F10 or LLC as appropriate). a and (b) In vitro cytotoxicity of B16F10 and LLC splenocytes from naïve mice and vaccinated mice against the target cell (B16F10 or LLC as appropriate). Modified Winn assay to determine if the cell-based vaccine could induce long-term immunity in vivo for B16F10 (c, e) and LLC (d, f). Inoculation groups consisted of (1) target cells (B16F10 or LLC) (2) splenocytes from naïve mice mixed with target cells and (3) splenocytes from vaccinated mice mixed with target cells