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Table 5 Overall and subgroups meta-analysis of COX-2 rs20417 polymorphism and HNSCC risk

From: COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

Overall and subgroups No. OR (95 % CI) Heterogeneity (I2%/p)
C vs. G (unadjusted and adjusted)
 Overall (unadjusted) 5 1.13 (0.62–2.05) 92 %/<0.10
 OSCC (unadjusted) 4 1.22 (0.52–2.89) 94 %/<0.10
 OSCC (adjusted) 1 0.73 (0.50–1.08) NA
 Asians (unadjusted) 4 1.22 (0.52–2.89) 94 %/<0.10
 Caucasian (unadjusted) 1 0.92 (0.70–1.21) NA
 HWE (Yes–unadjusted) 4 0.78 (0.52–1.18) 83 %/<0.10
 HWE (No–unadjusted) 1 6.08 (3.03–12.22) NA
CC vs. GG (unadjusted and adjusted)
 Overall (unadjusted) 5 1.17 (0.25–5.46) 80 %/<0.10
 Overall (adjusted) 2 0.53 (0.25–1.11) 0 %/0.71
 OSCC (unadjusted) 4 1.79 (0.10–31.00) 89 %/<0.10
 OSCC (adjusted) 1 0.44 (0.13–1.46) NA
 Asians (unadjusted) 4 1.79 (0.10–31.00) 89 %/<0.10
 Caucasian (unadjusted) 1 0.62 (0.25–1.50) NA
 HWE (Yes–unadjusted) 4 0.55 (0.27–1.13) 0 %/0.67
 HWE (No–unadjusted) 1 7.75 (1.70–35.33) NA
GC vs. GG (unadjusted and adjusted)
 Overall (unadjusted) 5 0.69 (0.36–1.35) 0 %/0.75
 Overall (adjusted) 2 0.90 (0.68–1.19) 9 %/0.29
 OSCC (unadjusted) 4 0.80 (0.30–2.09) 0 %/0.50
 OSCC (adjusted) 1 0.71 (0.42–1.18) NA
 Asians (unadjusted) 4 0.80 (0.30–2.09) 0 %/0.50
 Caucasian (unadjusted) 1 0.62 (0.24–1.55) NA
 HWE (Yes–unadjusted) 4 0.62 (0.30–1.29) 0 %/0.98
 HWE (No–unadjusted) 1 1.29 (0.23–7.31) NA
CC vs. CG + GG (unadjusted)
 Overall 5 1.15 (0.29–4.54) 76 %/0.02
 OSCC 4 1.76 (0.15–21.30) 85 %/<0.10
 Asians 4 1.76 (0.15–21.30) 85 %/<0.10
 Caucasian 1 0.62 (0.25–1.50) NA
 HWE (Yes) 4 0.58 (0.29–1.18) 0 %/0.84
 HWE (No) 1 6.43 (1.41–29.27) NA
CC + CG vs. GG (unadjusted and adjusted)
 Overall (unadjusted) 5 1.07 (0.51–2.24) 93 %/<0.10
 OSCC (unadjusted) 4 1.13 (0.39–3.26) 95 %/<0.10
 OSCC (adjusted) 1 0.22 (0.12–0.39) NA
 Asians (unadjusted) 4 1.13 (0.39–3.26) 95 %/<0.10
 Caucasian (unadjusted) 1 0.90 (0.70–1.30) NA
 HWE (Yes–unadjusted) 4 0.72 (0.39–1.33) 90 %/<0.10
 HWE (No–unadjusted) 1 6.45 (2.90–14.35) NA
  1. OSCC oral squamous cell carcinoma; HNSCC head and neck squamous cell carcinoma; LSCC laryngeal squamous cell carcinoma; OR odds ratio; CI confidence interval; NA not available; HWE Hardy–Weinberg Equilibrium