Table 5 Overall and subgroups meta-analysis of COX-2 rs20417 polymorphism and HNSCC risk
Overall and subgroups | No. | OR (95 % CI) | Heterogeneity (I2%/p) |
|---|---|---|---|
C vs. G (unadjusted and adjusted) | |||
 Overall (unadjusted) | 5 | 1.13 (0.62–2.05) | 92 %/<0.10 |
 OSCC (unadjusted) | 4 | 1.22 (0.52–2.89) | 94 %/<0.10 |
 OSCC (adjusted) | 1 | 0.73 (0.50–1.08) | NA |
 Asians (unadjusted) | 4 | 1.22 (0.52–2.89) | 94 %/<0.10 |
 Caucasian (unadjusted) | 1 | 0.92 (0.70–1.21) | NA |
 HWE (Yes–unadjusted) | 4 | 0.78 (0.52–1.18) | 83 %/<0.10 |
 HWE (No–unadjusted) | 1 | 6.08 (3.03–12.22) | NA |
CC vs. GG (unadjusted and adjusted) | |||
 Overall (unadjusted) | 5 | 1.17 (0.25–5.46) | 80 %/<0.10 |
 Overall (adjusted) | 2 | 0.53 (0.25–1.11) | 0 %/0.71 |
 OSCC (unadjusted) | 4 | 1.79 (0.10–31.00) | 89 %/<0.10 |
 OSCC (adjusted) | 1 | 0.44 (0.13–1.46) | NA |
 Asians (unadjusted) | 4 | 1.79 (0.10–31.00) | 89 %/<0.10 |
 Caucasian (unadjusted) | 1 | 0.62 (0.25–1.50) | NA |
 HWE (Yes–unadjusted) | 4 | 0.55 (0.27–1.13) | 0 %/0.67 |
 HWE (No–unadjusted) | 1 | 7.75 (1.70–35.33) | NA |
GC vs. GG (unadjusted and adjusted) | |||
 Overall (unadjusted) | 5 | 0.69 (0.36–1.35) | 0 %/0.75 |
 Overall (adjusted) | 2 | 0.90 (0.68–1.19) | 9 %/0.29 |
 OSCC (unadjusted) | 4 | 0.80 (0.30–2.09) | 0 %/0.50 |
 OSCC (adjusted) | 1 | 0.71 (0.42–1.18) | NA |
 Asians (unadjusted) | 4 | 0.80 (0.30–2.09) | 0 %/0.50 |
 Caucasian (unadjusted) | 1 | 0.62 (0.24–1.55) | NA |
 HWE (Yes–unadjusted) | 4 | 0.62 (0.30–1.29) | 0 %/0.98 |
 HWE (No–unadjusted) | 1 | 1.29 (0.23–7.31) | NA |
CC vs. CG + GG (unadjusted) | |||
 Overall | 5 | 1.15 (0.29–4.54) | 76 %/0.02 |
 OSCC | 4 | 1.76 (0.15–21.30) | 85 %/<0.10 |
 Asians | 4 | 1.76 (0.15–21.30) | 85 %/<0.10 |
 Caucasian | 1 | 0.62 (0.25–1.50) | NA |
 HWE (Yes) | 4 | 0.58 (0.29–1.18) | 0 %/0.84 |
 HWE (No) | 1 | 6.43 (1.41–29.27) | NA |
CC + CG vs. GG (unadjusted and adjusted) | |||
 Overall (unadjusted) | 5 | 1.07 (0.51–2.24) | 93 %/<0.10 |
 OSCC (unadjusted) | 4 | 1.13 (0.39–3.26) | 95 %/<0.10 |
 OSCC (adjusted) | 1 | 0.22 (0.12–0.39) | NA |
 Asians (unadjusted) | 4 | 1.13 (0.39–3.26) | 95 %/<0.10 |
 Caucasian (unadjusted) | 1 | 0.90 (0.70–1.30) | NA |
 HWE (Yes–unadjusted) | 4 | 0.72 (0.39–1.33) | 90 %/<0.10 |
 HWE (No–unadjusted) | 1 | 6.45 (2.90–14.35) | NA |