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Table 2 Adjustment and adjusted data of included studies

From: COX-2 rs689466, rs5275, and rs20417 polymorphisms and risk of head and neck squamous cell carcinoma: a meta-analysis of adjusted and unadjusted data

Study Form of disease Reference OR (95 % CI) Adjustment
rs689466 (−1195G > A)
 Peters 2009 HNSCC GG: 1.00 GA: 0.79 (0.58–1.07); age (continuous), sex, smoking (continuous, 5 levels), and alcohol consumption (continuous, 3 levels)
AA: 1.24 (0.60–2.56)
 Mittal 2010 OSCC GG: 1.00 GA: 3.07 (0.66–13.24); age, gender
AA: 2.22 (0.52–9.50)
G: 1.00 A: 1.03 (0.60–1.42)
 Chang 2013 HNSCC GG: 1.00 GA: 0.86 (0.56–1.32); sex, age, education, cigarette smoking (pack-year categories), betel quid chewing (pack-year categories), and alcohol drinking (frequency)
AA: 1.23 (0.72–2.09);
GA + AA: 0.96 (0.64–1.43);
G: 1.00 A: 1.08 (0.83–1.40)
 Niu 2014 HNSCC GG: 1.00 GA:0.85 (0.60–1.21) age, sex, smoking status, and drinking status
AA: 1.01 (0.69–1.50)
GA + AA: 0.91 (0.65–1.26)
OSCC GG: 1.00 GA: 0.74 (0.49–1.11)
AA: 0.87 (0.55–1.39)
GA + AA:0.78 (0.53–1.14)
LSCC GG: 1.00 GA:1.16 (0.65–2.09)
AA:1.43 (0.75–2.75)
GA + AA:1.23 (0.71–2.15)
rs5275 (8473 T > C)
 Campa 2007 HNSCC TT: 1.00 TC: 1.03 (0.82–1.28); age, sex, center, tobacco consumption (packyears), and years of alcohol consumption
CC: 0.75 (0.51–1.10);
TC + CC: 0.97 (0.78–1.20)
OPSCC TT: 1.00 TC: 1.16 (0.86–1.58);
CC: 0.91 (0.53–1.54);
TC + CC: 1.11 (0.83–1.49)
LSCC TT: 1.00 TC: 0.88 (0.63–1.22);
CC: 0.60 (0.34–1.05);
TC + CC: 0.82 (0.60–1.12)
 Mittal 2010 OSCC TT: 1.00 TC: 0.27 (0.03–2.26); age, gender
CC: 0.28 (0.03–2.33)
T: 1.00 C: 0.88 (0.55–1.40)
 Chang 2013 HNSCC TT: 1.00 TC: 1.04 (0.69–1.56); sex, age, education, cigarette smoking (pack-year categories), betel quid chewing (pack-year categories), and alcohol drinking (frequency)
CC: 1.89 (0.74–4.82);
TC + CC: 1.12 (0.75–1.65)
 Niu 2014 HNSCC TT: 1.00 TC: 0.90 (0.66–1.22); age, sex, smoking status, and drinking status
CC: 1.48 (0.68–3.25);
TC + CC: 0.94 (0.70–1.26)
OSCC TT: 1.00 TC: 0.86 (0.58–1.26);
CC: 1.03 (0.36–2.97);
TC + CC: 0.87 (0.60–1.27)
LSCC TT: 1.00 TC: 1.02 (0.63–1.64);
CC: 1.62 (0.54–4.88);
TC + CC: 1.07 (0.67–1.69)
rs20417 (−765G > C)
 Lin 2008 OSCC GG: 1.00 GC + CC: 0.22 (0.12–0.39) age, gender, ethnicity, educational level, and habits of betel quid chewing, cigarette smoking, and alcohol drinking
 Peters 2009 HNSCC GG: 1.00 GC: 0.99 (0.71–1.40); age (continuous), sex, smoking (continuous, 5 levels), and alcohol consumption (continuous, 3 levels)
CC: 0.59 (0.23–1.49)
 Mittal 2010 OSCC GG: 1.00 GC: 0.71 (0.42–1.18); age, gender
CC: 0.44 (0.13–1.46)
G: 1.00 C: 0.73 (0.50–1.08)
  1. OSCC oral squamous cell carcinoma; HNSCC head and neck squamous cell carcinoma; LSCC laryngeal squamous cell carcinoma; OR odds ratio; CI confidence interval