Table 2 Adjustment and adjusted data of included studies
Study | Form of disease | Reference | OR (95 % CI) | Adjustment |
|---|---|---|---|---|
rs689466 (−1195G > A) | ||||
 Peters 2009 | HNSCC | GG: 1.00 | GA: 0.79 (0.58–1.07); | age (continuous), sex, smoking (continuous, 5 levels), and alcohol consumption (continuous, 3 levels) |
AA: 1.24 (0.60–2.56) | ||||
 Mittal 2010 | OSCC | GG: 1.00 | GA: 3.07 (0.66–13.24); | age, gender |
AA: 2.22 (0.52–9.50) | ||||
G: 1.00 | A: 1.03 (0.60–1.42) | |||
 Chang 2013 | HNSCC | GG: 1.00 | GA: 0.86 (0.56–1.32); | sex, age, education, cigarette smoking (pack-year categories), betel quid chewing (pack-year categories), and alcohol drinking (frequency) |
AA: 1.23 (0.72–2.09); | ||||
GA + AA: 0.96 (0.64–1.43); | ||||
G: 1.00 | A: 1.08 (0.83–1.40) | |||
 Niu 2014 | HNSCC | GG: 1.00 | GA:0.85 (0.60–1.21) | age, sex, smoking status, and drinking status |
AA: 1.01 (0.69–1.50) | ||||
GA + AA: 0.91 (0.65–1.26) | ||||
OSCC | GG: 1.00 | GA: 0.74 (0.49–1.11) | ||
AA: 0.87 (0.55–1.39) | ||||
GA + AA:0.78 (0.53–1.14) | ||||
LSCC | GG: 1.00 | GA:1.16 (0.65–2.09) | ||
AA:1.43 (0.75–2.75) | ||||
GA + AA:1.23 (0.71–2.15) | ||||
rs5275 (8473 T > C) | ||||
 Campa 2007 | HNSCC | TT: 1.00 | TC: 1.03 (0.82–1.28); | age, sex, center, tobacco consumption (packyears), and years of alcohol consumption |
CC: 0.75 (0.51–1.10); | ||||
TC + CC: 0.97 (0.78–1.20) | ||||
OPSCC | TT: 1.00 | TC: 1.16 (0.86–1.58); | ||
CC: 0.91 (0.53–1.54); | ||||
TC + CC: 1.11 (0.83–1.49) | ||||
LSCC | TT: 1.00 | TC: 0.88 (0.63–1.22); | ||
CC: 0.60 (0.34–1.05); | ||||
TC + CC: 0.82 (0.60–1.12) | ||||
 Mittal 2010 | OSCC | TT: 1.00 | TC: 0.27 (0.03–2.26); | age, gender |
CC: 0.28 (0.03–2.33) | ||||
T: 1.00 | C: 0.88 (0.55–1.40) | |||
 Chang 2013 | HNSCC | TT: 1.00 | TC: 1.04 (0.69–1.56); | sex, age, education, cigarette smoking (pack-year categories), betel quid chewing (pack-year categories), and alcohol drinking (frequency) |
CC: 1.89 (0.74–4.82); | ||||
TC + CC: 1.12 (0.75–1.65) | ||||
 Niu 2014 | HNSCC | TT: 1.00 | TC: 0.90 (0.66–1.22); | age, sex, smoking status, and drinking status |
CC: 1.48 (0.68–3.25); | ||||
TC + CC: 0.94 (0.70–1.26) | ||||
OSCC | TT: 1.00 | TC: 0.86 (0.58–1.26); | ||
CC: 1.03 (0.36–2.97); | ||||
TC + CC: 0.87 (0.60–1.27) | ||||
LSCC | TT: 1.00 | TC: 1.02 (0.63–1.64); | ||
CC: 1.62 (0.54–4.88); | ||||
TC + CC: 1.07 (0.67–1.69) | ||||
rs20417 (−765G > C) | ||||
 Lin 2008 | OSCC | GG: 1.00 | GC + CC: 0.22 (0.12–0.39) | age, gender, ethnicity, educational level, and habits of betel quid chewing, cigarette smoking, and alcohol drinking |
 Peters 2009 | HNSCC | GG: 1.00 | GC: 0.99 (0.71–1.40); | age (continuous), sex, smoking (continuous, 5 levels), and alcohol consumption (continuous, 3 levels) |
CC: 0.59 (0.23–1.49) | ||||
 Mittal 2010 | OSCC | GG: 1.00 | GC: 0.71 (0.42–1.18); | age, gender |
CC: 0.44 (0.13–1.46) | ||||
G: 1.00 | C: 0.73 (0.50–1.08) | |||