Fig. 4
Knockdown of EHD1 increased sensitivity to CDDP in CDDP-resistant NSCLC cells. a Western blotting analysis of EHD1 levels. b Inhibitory effect of CDDP was measured in CDDP-resistant NSCLC cells using the CCK-8 assay at 24Ā h. c The IC50 values for CDDP were determined in CDDP-resistant NSCLC cells at 24Ā h. d Inhibitory effect of CDDP was measured at 48Ā h. e The IC50 values for CDDP were determined at 48Ā h. f Annexin-V-FITC/PI staining was analysed by flow cytometry in CDDP-resistant NSCLC cells after treatment with CDDP for 24Ā h. g The histogram demonstrates the percentage of early apoptotic in CDDP-resistant NSCLC cells in response to CDDP concentrations of 0, 2.5, 5 and 10Ā Ī¼M