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Table 1 Association of clinical characteristics and pathological factors with early recurrence

From: Association of preoperative EpCAM Circulating Tumor Cells and peripheral Treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection

Variables

Early recurrence

P

No

Yes

Age

≤50

15

8

0.365

>50

20

6

Sex

male

26

10

0.838

female

9

4

HBsAg

Negative

7

2

0.641

Postive

28

12

HBeAg

Negative

27

9

0.357

 

Postive

8

5

HBVDNA

<5*102

21

10

0.453

>5*102

14

4

ALT (U/L)

≤40

30

9

0.412

>40

5

5

AFP (ng/ml)

≤400

23

10

0.768

>400

12

4

EpCAM mRNA+ CTC (2-ΔΔCq)

Low (<2.22)

28

4

<0.001*

High (≥2.22)

7

10

Treg/CD4+ (%)

<5.07

31

9

0.020*

≥5.07

4

5

Child-Pugh stage

A

34

14

0.523

B

1

0

Liver cirrhosis

No

9

3

0.753

Yes

26

11

Tumor number

Single

33

11

0.101

Multiple

2

3

Tumor size (cm)

≤5

21

8

0.854

>5

14

6

Tumor encapsulation

Complete

16

5

0.523

None

19

9

Satellite lesion

No

34

10

0.007*

Yes

1

4

Vascular invasion

No

21

4

0.047*

Yes

14

10

Edmondson stage

I-II

22

9

0.925

II-IV

13

5

BCLC stage

0 + A

33

11

0.101

B + C

2

3

  1. Abbreviations: ALT alanine transaminase, HBsAg Hepatitis B surface antigen, AFP alphafetoprotein, HBeAg Hepatitis B e antigen. p value of < 0.05 was considered statistically-significant