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Table 1 Association of clinical characteristics and pathological factors with early recurrence

From: Association of preoperative EpCAM Circulating Tumor Cells and peripheral Treg cell levels with early recurrence of hepatocellular carcinoma following radical hepatic resection

Variables Early recurrence P
No Yes
Age ≤50 15 8 0.365
>50 20 6
Sex male 26 10 0.838
female 9 4
HBsAg Negative 7 2 0.641
Postive 28 12
HBeAg Negative 27 9 0.357
  Postive 8 5
HBVDNA <5*102 21 10 0.453
>5*102 14 4
ALT (U/L) ≤40 30 9 0.412
>40 5 5
AFP (ng/ml) ≤400 23 10 0.768
>400 12 4
EpCAM mRNA+ CTC (2-ΔΔCq) Low (<2.22) 28 4 <0.001*
High (≥2.22) 7 10
Treg/CD4+ (%) <5.07 31 9 0.020*
≥5.07 4 5
Child-Pugh stage A 34 14 0.523
B 1 0
Liver cirrhosis No 9 3 0.753
Yes 26 11
Tumor number Single 33 11 0.101
Multiple 2 3
Tumor size (cm) ≤5 21 8 0.854
>5 14 6
Tumor encapsulation Complete 16 5 0.523
None 19 9
Satellite lesion No 34 10 0.007*
Yes 1 4
Vascular invasion No 21 4 0.047*
Yes 14 10
Edmondson stage I-II 22 9 0.925
II-IV 13 5
BCLC stage 0 + A 33 11 0.101
B + C 2 3
  1. Abbreviations: ALT alanine transaminase, HBsAg Hepatitis B surface antigen, AFP alphafetoprotein, HBeAg Hepatitis B e antigen. p value of < 0.05 was considered statistically-significant