Table 2 Dose reduction and treatment interruptions due to AEs
Treatment interruption | Total (n = 279), n (%) | No history of heart or liver diseases (n = 215), n (%) | History of heart diseases (n = 23), n (%) | History of liver diseases (n = 44), n (%) | p value* | p value** |
|---|---|---|---|---|---|---|
Dose reduction | 13 (4.7) | 9 (4.2) | 1 (4.3) | 3 (6.8) | 1.000 | 0.435 |
Treatment discontinuation | 8 (2.9) | 2 (0.9) | 2 (8.7) | 5 (11.4) | 0.048 | 0.002 |