TY - CHAP AU - Hogendoorn, P. C. W. AU - Bovée, J. V. M. G. AU - Nielsen, G. P. ED - Fletcher, C. D. M. ED - Bridge, J. A. ED - Hogendoorn, P. C. W. ED - Mertens, F. PY - 2013 DA - 2013// TI - Chondrosarcoma (grades I-III), including primary and secondary variants and periosteal chondrosarcoma BT - WHO Classification of Tumours of Soft Tissue and Bone PB - IARC CY - Lyon ID - Hogendoorn2013 ER - TY - JOUR AU - Gelderblom, H. AU - Hogendoorn, P. C. AU - Dijkstra, S. D. AU - Rijswijk, C. S. AU - Krol, A. D. AU - Taminiau, A. H. PY - 2008 DA - 2008// TI - The clinical approach towards chondrosarcoma JO - Oncologist VL - 13 UR - https://doi.org/10.1634/theoncologist.2007-0237 DO - 10.1634/theoncologist.2007-0237 ID - Gelderblom2008 ER - TY - JOUR AU - Bjornsson, J. AU - McLeod, R. A. AU - Unni, K. K. AU - Ilstrup, D. M. AU - Pritchard, D. J. PY - 1998 DA - 1998// TI - Primary chondrosarcoma of long bones and limb girdles JO - Cancer VL - 83 UR - https://doi.org/3.0.CO;2-U DO - 3.0.CO;2-U ID - Bjornsson1998 ER - TY - CHAP AU - Inwards, C. AU - Hogendoorn, P. C. W. ED - Fletcher, C. D. M. ED - Bridge, J. A. ED - Hogendoorn, P. C. W. ED - Mertens, F. PY - 2013 DA - 2013// TI - Dedifferentiated chondrosarcoma BT - WHO Classification of Tumours of Soft Tissue and Bone PB - IARC CY - Lyon ID - Inwards2013 ER - TY - CHAP AU - Nakashima, Y. AU - Pinieux, G. AU - Ladanyi, M. ED - Fletcher, C. D. M. ED - Bridge, J. A. ED - Hogendoorn, P. C. W. ED - Mertens, F. PY - 2013 DA - 2013// TI - Mesenchymal chondrosarcoma BT - WHO Classification of Tumours of Soft Tissue and Bone PB - IARC CY - Lyon ID - Nakashima2013 ER - TY - JOUR AU - Frezza, A. M. AU - Cesari, M. AU - Baumhoer, D. AU - Biau, D. AU - Bielack, S. AU - Campanacci, D. A. PY - 2015 DA - 2015// TI - Mesenchymal chondrosarcoma: prognostic factors and outcome in 113 patients. A European Musculoskeletal Oncology Society study JO - Eur J Cancer VL - 51 UR - https://doi.org/10.1016/j.ejca.2014.11.007 DO - 10.1016/j.ejca.2014.11.007 ID - Frezza2015 ER - TY - JOUR AU - Xu, J. AU - Li, D. AU - Xie, L. AU - Tang, S. AU - Guo, W. PY - 2015 DA - 2015// TI - Mesenchymal chondrosarcoma of bone and soft tissue: a systematic review of 107 patients in the past 20 years JO - PLoS One VL - 10 UR - https://doi.org/10.1371/journal.pone.0122216 DO - 10.1371/journal.pone.0122216 ID - Xu2015 ER - TY - STD TI - van Maldegem AM, Gelderblom H, Palmerini E, Dijkstra SD, Gambarotti M, Ruggieri P et al. Outcome of advanced, unresectable conventional central chondrosarcoma. Cancer. 2014. doi:10.1002/cncr.28845. ID - ref8 ER - TY - JOUR AU - Italiano, A. AU - Mir, O. AU - Cioffi, A. AU - Palmerini, E. AU - Piperno-Neumann, S. AU - Perrin, C. PY - 2013 DA - 2013// TI - Advanced chondrosarcomas: role of chemotherapy and survival JO - Ann Oncol VL - 24 UR - https://doi.org/10.1093/annonc/mdt374 DO - 10.1093/annonc/mdt374 ID - Italiano2013 ER - TY - JOUR AU - Bovee, J. V. AU - Hogendoorn, P. C. AU - Wunder, J. S. AU - Alman, B. A. PY - 2010 DA - 2010// TI - Cartilage tumours and bone development: molecular pathology and possible therapeutic targets JO - Nat Rev Cancer VL - 10 UR - https://doi.org/10.1038/nrc2869 DO - 10.1038/nrc2869 ID - Bovee2010 ER - TY - JOUR AU - Oosterwijk, J. G. AU - Anninga, J. K. AU - Gelderblom, H. AU - Cleton-Jansen, A. M. AU - Bovee, J. V. PY - 2013 DA - 2013// TI - Update on targets and novel treatment options for high-grade osteosarcoma and chondrosarcoma JO - Hematol Oncol Clin North Am VL - 27 UR - https://doi.org/10.1016/j.hoc.2013.07.012 DO - 10.1016/j.hoc.2013.07.012 ID - Oosterwijk2013 ER - TY - JOUR AU - Pollak, M. PY - 2012 DA - 2012// TI - The insulin and insulin-like growth factor receptor family in neoplasia: an update JO - Nat Rev Cancer VL - 12 ID - Pollak2012 ER - TY - JOUR AU - Zhang, Y. X. AU - Oosterwijk, J. G. AU - Sicinska, E. AU - Moss, S. AU - Remillard, S. P. AU - Wezel, T. PY - 2013 DA - 2013// TI - Functional profiling of receptor tyrosine kinases and downstream signaling in human chondrosarcomas identifies pathways for rational targeted therapy JO - Clin Cancer Res VL - 19 UR - https://doi.org/10.1158/1078-0432.CCR-12-3647 DO - 10.1158/1078-0432.CCR-12-3647 ID - Zhang2013 ER - TY - JOUR AU - Schrage, Y. M. AU - Briaire-de Bruijn, I. H. AU - Miranda, N. F. AU - Oosterwijk, J. AU - Taminiau, A. H. AU - Wezel, T. PY - 2009 DA - 2009// TI - Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment JO - Cancer Res VL - 69 UR - https://doi.org/10.1158/0008-5472.CAN-08-4801 DO - 10.1158/0008-5472.CAN-08-4801 ID - Schrage2009 ER - TY - JOUR AU - Jang, J. H. AU - Chung, C. P. PY - 2005 DA - 2005// TI - Tenascin-C promotes cell survival by activation of Akt in human chondrosarcoma cell JO - Cancer Lett VL - 229 UR - https://doi.org/10.1016/j.canlet.2004.12.012 DO - 10.1016/j.canlet.2004.12.012 ID - Jang2005 ER - TY - JOUR AU - Oosterwijk, J. G. AU - Ruler, M. A. AU - Briaire-de Bruijn, I. H. AU - Herpers, B. AU - Gelderblom, H. AU - Water, B. PY - 2013 DA - 2013// TI - Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells JO - Br J Cancer VL - 109 UR - https://doi.org/10.1038/bjc.2013.451 DO - 10.1038/bjc.2013.451 ID - Oosterwijk2013 ER - TY - JOUR AU - Galoian, K. A. AU - Guettouche, T. AU - Issac, B. AU - Qureshi, A. AU - Temple, H. T. PY - 2014 DA - 2014// TI - Regulation of onco and tumor suppressor MiRNAs by mTORC1 inhibitor PRP-1 in human chondrosarcoma JO - Tumour Biol VL - 35 UR - https://doi.org/10.1007/s13277-013-1309-7 DO - 10.1007/s13277-013-1309-7 ID - Galoian2014 ER - TY - JOUR AU - Schwartz, G. K. AU - Tap, W. D. AU - Qin, L. X. AU - Livingston, M. B. AU - Undevia, S. D. AU - Chmielowski, B. PY - 2013 DA - 2013// TI - Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial JO - Lancet Oncol VL - 14 UR - https://doi.org/10.1016/S1470-2045(13)70049-4 DO - 10.1016/S1470-2045(13)70049-4 ID - Schwartz2013 ER - TY - JOUR AU - Takigawa, M. AU - Okawa, T. AU - Pan, H. AU - Aoki, C. AU - Takahashi, K. AU - Zue, J. PY - 1997 DA - 1997// TI - Insulin-like growth factors I and II are autocrine factors in stimulating proteoglycan synthesis, a marker of differentiated chondrocytes, acting through their respective receptors on a clonal human chondrosarcoma-derived chondrocyte cell line, HCS-2/8 JO - Endocrinology VL - 138 ID - Takigawa1997 ER - TY - JOUR AU - Matsumura, T. AU - Whelan, M. C. AU - Li, X. Q. AU - Trippel, S. B. PY - 2000 DA - 2000// TI - Regulation by IGF-I and TGF-beta1 of Swarm-rat chondrosarcoma chondrocytes JO - J Orthop Res VL - 18 UR - https://doi.org/10.1002/jor.1100180305 DO - 10.1002/jor.1100180305 ID - Matsumura2000 ER - TY - JOUR AU - Seong, S. C. AU - Matsumura, T. AU - Lee, F. Y. AU - Whelan, M. C. AU - Li, X. Q. AU - Trippel, S. B. PY - 1994 DA - 1994// TI - Insulin-like growth factor I regulation of Swarm rat chondrosarcoma chondrocytes in culture JO - Exp Cell Res VL - 211 UR - https://doi.org/10.1006/excr.1994.1083 DO - 10.1006/excr.1994.1083 ID - Seong1994 ER - TY - JOUR AU - Ho, L. AU - Stojanovski, A. AU - Whetstone, H. AU - Wei, Q. X. AU - Mau, E. AU - Wunder, J. S. PY - 2009 DA - 2009// TI - Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors JO - Cancer Cell VL - 16 UR - https://doi.org/10.1016/j.ccr.2009.05.013 DO - 10.1016/j.ccr.2009.05.013 ID - Ho2009 ER - TY - JOUR AU - Wu, C. M. AU - Li, T. M. AU - Hsu, S. F. AU - Su, Y. C. AU - Kao, S. T. AU - Fong, Y. C. PY - 2011 DA - 2011// TI - IGF-I enhances alpha5beta1 integrin expression and cell motility in human chondrosarcoma cells JO - J Cell Physiol VL - 226 UR - https://doi.org/10.1002/jcp.22688 DO - 10.1002/jcp.22688 ID - Wu2011 ER - TY - JOUR AU - Kuijjer, M. L. AU - Peterse, E. F. AU - Akker, B. E. AU - Briaire-de Bruijn, I. H. AU - Serra, M. AU - Meza-Zepeda, L. A. PY - 2013 DA - 2013// TI - IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma JO - BMC Cancer VL - 13 UR - https://doi.org/10.1186/1471-2407-13-245 DO - 10.1186/1471-2407-13-245 ID - Kuijjer2013 ER - TY - JOUR AU - Valen, F. AU - Harrer, H. AU - Hotfilder, M. AU - Dirksen, U. AU - Pap, T. AU - Gosheger, G. PY - 2012 DA - 2012// TI - A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells JO - Sarcoma VL - 2012 ID - Valen2012 ER - TY - JOUR AU - Jagasia, A. A. AU - Block, J. A. AU - Qureshi, A. AU - Diaz, M. O. AU - Nobori, T. AU - Gitelis, S. PY - 1996 DA - 1996// TI - Chromosome 9 related aberrations and deletions of the CDKN2 and MTS2 putative tumor suppressor genes in human chondrosarcomas JO - Cancer Lett VL - 105 UR - https://doi.org/10.1016/0304-3835(96)04274-7 DO - 10.1016/0304-3835(96)04274-7 ID - Jagasia1996 ER - TY - JOUR AU - Gil-Benso, R. AU - Lopez-Gines, C. AU - Lopez-Guerrero, J. A. AU - Carda, C. AU - Callaghan, R. C. AU - Navarro, S. PY - 2003 DA - 2003// TI - Establishment and characterization of a continuous human chondrosarcoma cell line, ch-2879: comparative histologic and genetic studies with its tumor of origin JO - Lab Invest VL - 83 UR - https://doi.org/10.1097/01.LAB.0000073131.34648.EA DO - 10.1097/01.LAB.0000073131.34648.EA ID - Gil-Benso2003 ER - TY - JOUR AU - Kunisada, T. AU - Miyazaki, M. AU - Mihara, K. AU - Gao, C. AU - Kawai, A. AU - Inoue, H. PY - 1998 DA - 1998// TI - A new human chondrosarcoma cell line (OUMS-27) that maintains chondrocytic differentiation JO - Int J Cancer VL - 77 UR - https://doi.org/3.0.CO;2-1 DO - 3.0.CO;2-1 ID - Kunisada1998 ER - TY - JOUR AU - Oosterwijk, J. G. AU - Jong, D. AU - Ruler, M. A. AU - Hogendoorn, P. C. AU - Dijkstra, P. D. AU - Rijswijk, C. S. PY - 2012 DA - 2012// TI - Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone JO - BMC Cancer VL - 12 UR - https://doi.org/10.1186/1471-2407-12-375 DO - 10.1186/1471-2407-12-375 ID - Oosterwijk2012 ER - TY - JOUR AU - Calabuig-Farinas, S. AU - Benso, R. G. AU - Szuhai, K. AU - Machado, I. AU - Lopez-Guerrero, J. A. AU - Jong, D. PY - 2012 DA - 2012// TI - Characterization of a new human cell line (CH-3573) derived from a grade II chondrosarcoma with matrix production JO - Pathol Oncol Res VL - 18 UR - https://doi.org/10.1007/s12253-012-9505-0 DO - 10.1007/s12253-012-9505-0 ID - Calabuig-Farinas2012 ER - TY - JOUR AU - Kudo, N. AU - Ogose, A. AU - Hotta, T. AU - Kawashima, H. AU - Gu, W. AU - Umezu, H. PY - 2007 DA - 2007// TI - Establishment of novel human dedifferentiated chondrosarcoma cell line with osteoblastic differentiation JO - Virchows Arch VL - 451 UR - https://doi.org/10.1007/s00428-007-0426-3 DO - 10.1007/s00428-007-0426-3 ID - Kudo2007 ER - TY - JOUR AU - Whang-Peng, J. AU - Triche, T. J. AU - Knutsen, T. AU - Miser, J. AU - Kao-Shan, S. AU - Tsai, S. PY - 1986 DA - 1986// TI - Cytogenetic characterization of selected small round cell tumors of childhood JO - Cancer Genet Cytogenet VL - 21 UR - https://doi.org/10.1016/0165-4608(86)90001-4 DO - 10.1016/0165-4608(86)90001-4 ID - Whang-Peng1986 ER - TY - JOUR AU - Cleton-Jansen, A. M. AU - Beerendonk, H. M. AU - Baelde, H. J. AU - Bovee, J. V. AU - Karperien, M. AU - Hogendoorn, P. C. PY - 2005 DA - 2005// TI - Estrogen signaling is active in cartilaginous tumors: implications for antiestrogen therapy as treatment option of metastasized or irresectable chondrosarcoma JO - Clin Cancer Res VL - 11 UR - https://doi.org/10.1158/1078-0432.CCR-05-1253 DO - 10.1158/1078-0432.CCR-05-1253 ID - Cleton-Jansen2005 ER - TY - JOUR AU - Rozeman, L. B. AU - Hameetman, L. AU - Cleton-Jansen, A. M. AU - Taminiau, A. H. AU - Hogendoorn, P. C. AU - Bovee, J. V. PY - 2005 DA - 2005// TI - Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas JO - J Pathol VL - 205 UR - https://doi.org/10.1002/path.1723 DO - 10.1002/path.1723 ID - Rozeman2005 ER - TY - JOUR AU - Hameetman, L. AU - Rozeman, L. B. AU - Lombaerts, M. AU - Oosting, J. AU - Taminiau, A. H. AU - Cleton-Jansen, A. M. PY - 2006 DA - 2006// TI - Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog signalling JO - J Pathol VL - 209 UR - https://doi.org/10.1002/path.2008 DO - 10.1002/path.2008 ID - Hameetman2006 ER - TY - JOUR AU - Oosterwijk, J. G. AU - Herpers, B. AU - Meijer, D. AU - Briaire-de Bruijn, I. H. AU - Cleton-Jansen, A. M. AU - Gelderblom, H. PY - 2012 DA - 2012// TI - Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance JO - Ann Oncol VL - 23 UR - https://doi.org/10.1093/annonc/mdr512 DO - 10.1093/annonc/mdr512 ID - Oosterwijk2012 ER - TY - JOUR AU - Atienzar, F. A. AU - Tilmant, K. AU - Gerets, H. H. AU - Toussaint, G. AU - Speeckaert, S. AU - Hanon, E. PY - 2011 DA - 2011// TI - The use of real-time cell analyzer technology in drug discovery: defining optimal cell culture conditions and assay reproducibility with different adherent cellular models JO - J Biomol Screen VL - 16 UR - https://doi.org/10.1177/1087057111402825 DO - 10.1177/1087057111402825 ID - Atienzar2011 ER - TY - STD TI - Baranski Z, Booij TH, Cleton-Jansen AM, Price LS, van de Water B, Bovee JV et al. Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma. The Journal of pathology. 2015. doi:10.1002/path.4528. ID - ref38 ER - TY - JOUR AU - Oosterwijk, J. G. AU - Meijer, D. AU - Ruler, M. A. AU - Akker, B. E. AU - Oosting, J. AU - Krenacs, T. PY - 2013 DA - 2013// TI - Screening for potential targets for therapy in mesenchymal, clear cell, and dedifferentiated chondrosarcoma reveals Bcl-2 family members and TGFbeta as potential targets JO - Am J Pathol VL - 182 UR - https://doi.org/10.1016/j.ajpath.2012.12.036 DO - 10.1016/j.ajpath.2012.12.036 ID - Oosterwijk2013 ER - TY - JOUR AU - Yuen, J. S. AU - Macaulay, V. M. PY - 2008 DA - 2008// TI - Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer JO - Expert OpinTherTargets VL - 12 ID - Yuen2008 ER - TY - JOUR AU - Mulvihill, M. J. AU - Cooke, A. AU - Rosenfeld-Franklin, M. AU - Buck, E. AU - Foreman, K. AU - Landfair, D. PY - 2009 DA - 2009// TI - Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor JO - Future Med Chem VL - 1 UR - https://doi.org/10.4155/fmc.09.89 DO - 10.4155/fmc.09.89 ID - Mulvihill2009 ER - TY - JOUR AU - Bradbury, A. AU - Pluckthun, A. PY - 2015 DA - 2015// TI - Reproducibility: Standardize antibodies used in research JO - Nature VL - 518 UR - https://doi.org/10.1038/518027a DO - 10.1038/518027a ID - Bradbury2015 ER - TY - JOUR AU - Begley, C. G. AU - Ellis, L. M. PY - 2012 DA - 2012// TI - Drug development: Raise standards for preclinical cancer research JO - Nature VL - 483 UR - https://doi.org/10.1038/483531a DO - 10.1038/483531a ID - Begley2012 ER - TY - JOUR AU - Olmos, D. AU - Postel-Vinay, S. AU - Molife, L. R. AU - Okuno, S. H. AU - Schuetze, S. M. AU - Paccagnella, M. L. PY - 2010 DA - 2010// TI - Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing’s sarcoma: a phase 1 expansion cohort study JO - Lancet Oncol VL - 11 UR - https://doi.org/10.1016/S1470-2045(09)70354-7 DO - 10.1016/S1470-2045(09)70354-7 ID - Olmos2010 ER - TY - JOUR AU - Prieur, A. AU - Tirode, F. AU - Cohen, P. AU - Delattre, O. PY - 2004 DA - 2004// TI - EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3 JO - Mol Cell Biol VL - 24 UR - https://doi.org/10.1128/MCB.24.16.7275-7283.2004 DO - 10.1128/MCB.24.16.7275-7283.2004 ID - Prieur2004 ER - TY - JOUR AU - Jogie-Brahim, S. AU - Feldman, D. AU - Oh, Y. PY - 2009 DA - 2009// TI - Unraveling insulin-like growth factor binding protein-3 actions in human disease JO - Endocr Rev VL - 30 UR - https://doi.org/10.1210/er.2008-0028 DO - 10.1210/er.2008-0028 ID - Jogie-Brahim2009 ER - TY - JOUR AU - Olmos, D. AU - Tan, D. S. AU - Jones, R. L. AU - Judson, I. R. PY - 2010 DA - 2010// TI - Biological rationale and current clinical experience with anti-insulin-like growth factor 1 receptor monoclonal antibodies in treating sarcoma: twenty years from the bench to the bedside JO - Cancer J VL - 16 UR - https://doi.org/10.1097/PPO.0b013e3181dbebf9 DO - 10.1097/PPO.0b013e3181dbebf9 ID - Olmos2010 ER - TY - JOUR AU - Fulzele, K. AU - DiGirolamo, D. J. AU - Liu, Z. AU - Xu, J. AU - Messina, J. L. AU - Clemens, T. L. PY - 2007 DA - 2007// TI - Disruption of the insulin-like growth factor type 1 receptor in osteoblasts enhances insulin signaling and action JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M700651200 DO - 10.1074/jbc.M700651200 ID - Fulzele2007 ER - TY - JOUR AU - Garofalo, C. AU - Manara, M. C. AU - Nicoletti, G. AU - Marino, M. T. AU - Lollini, P. L. AU - Astolfi, A. PY - 2011 DA - 2011// TI - Efficacy of and resistance to anti-IGF-1R therapies in Ewing’s sarcoma is dependent on insulin receptor signaling JO - Oncogene VL - 30 UR - https://doi.org/10.1038/onc.2010.640 DO - 10.1038/onc.2010.640 ID - Garofalo2011 ER -