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Table 4 Breakdown of positive and negative test results on HC2, cobas, and APTIMA, by the number and risk level of HPV genotypes detected on CLART

From: Cross-reactivity profiles of hybrid capture II, cobas, and APTIMA human papillomavirus assays: split-sample study

Risk level of detected genotypes Number of genotypes HC2 cobas APTIMA
Negative test result Positive test result Total Negative test result Positive test result Total Negative test result Positive test result Total
Only low-risk 1 410 (84 %) 79 (16 %) 489 390 (89 %) 47 (11 %) 437 412 (94 %) 25 (6 %) 437
2 72 (80 %) 18 (20 %) 90 66 (85 %) 12 (15 %) 78 73 (94 %) 5 (6 %) 78
3 18 (69 %) 8 (31 %) 26 16 (84 %) 3 (16 %) 19 16 (84 %) 3 (16 %) 19
≥4 6 (60 %) 4 (40 %) 10 10 (100 %) 0 (0 %) 10 8 (80 %) 2 (20 %) 10
Total 506 (82 %) 109 (18 %) 615 482 (89 %) 62 (11 %) 544 509 (94 %) 35 (6 %) 544
Only high-risk 1 245 (50 %) 242 (50 %) 487 143 (27 %) 396 (73 %) 539 319 (59 %) 220 (41 %) 539
2 19 (10 %) 169 (90 %) 188 8 (5 %) 146 (95 %) 153 45 (29 %) 109 (71 %) 153
3 3 (6 %) 45 (94 %) 48 1 (2 %) 53 (98 %) 54 13 (24 %) 41 (76 %) 54
≥4 0 (0 %) 12 (100 %) 12 0 (0 %) 18 (100 %) 17 1 (6 %) 17 (94 %) 17
Total 267 (36 %) 468 (64 %) 735 152 (20 %) 613 (80 %) 765 378 (49 %) 387 (51 %) 765
Low-risk and high-risk 2 72 (46 %) 86 (54 %) 158 42 (20 %) 162 (79 %) 205 106 (52 %) 98 (48 %) 205
3 38 (25 %) 116 (75 %) 154 16 (10 %) 139 (90 %) 155 56 (36 %) 99 (64 %) 155
≥4 19 (9 %) 196 (91 %) 215 2 (1 %) 207 (99 %) 210 46 (22 %) 163 (78 %) 210
Total 129 (24 %) 398 (76 %) 527 60 (11 %) 508 (89 %) 568 208 (37 %) 360 (63 %) 568
No genotypes 0 3096 (98 %) 49 (2 %) 3145 2981 (95 %) 162 (5 %) 3143a 3089 (98 %) 56 (2 %) 3145
Total 5022 5020a 5022
  1. aTwo samples had an invalid test result on cobas. For both samples, HC2 and APTIMA test results were negative; CLART detected no genotypes; cytology on one sample was normal, and inadequate on the other sample