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Table 2 Overview of clinical parameters and relative serum expression of MMP7, MMP10 and MMP12

From: Serum MMP7, MMP10 and MMP12 level as negative prognostic markers in colon cancer patients

Patient Characteristics

N

Median relative serum expression

MMP7

p

MMP10

P

MMP12

p

Gender

  

0.049

 

0.138

 

0.004

 Male

51

1.21

 

1.22

 

1.19

 

 Female

24

0.97

 

0.95

 

0.88

 

Age at operation

  

0.013

 

0.003

 

0.253

 <median = 64 years

37

0.95

 

0.95

 

1.16

 

 ≥ median = 64 years

38

1.2

 

1.36

 

1.03

 

T-Stage

  

0.582

 

0.957

 

0.481

 T1

2

0.86

 

0.9

 

0.42

 

 T2

8

0.92

 

1.13

 

1.11

 

 T3

53

1.08

 

1.13

 

1.07

 

 T4

13

1.24

 

1.22

 

1.19

 

N-Stage

  

0.806

 

0.074

 

0.301

 Node negative

29

1.06

 

1.22

 

1.0

 

 Node positive

46

1.16

 

0.99

 

1.14

 

M-Stage

  

0.244

 

0.603

 

0.087

 M0

55

1.06

 

1.13

 

1.0

 

 M1

23

1.26

 

1.13

 

1.19

 

L-Stage

  

0.629

 

0.085

 

0.593

 L0

61

1.06

 

1.18

 

1.06

 

 L1

14

1.25

 

0.81

 

1.14

 

V-Stage

  

0.067

 

0.321

 

0.018

 V0

69

1.06

 

1.13

 

1.06

 

 V1

6

2.41

 

1.86

 

1.32

 

Micro satellite stage

  

0.053

 

0.845

 

0.844

 MSS

5

0.68

 

0.76

 

0.47

 

 MSI

2

1.16

 

0.95

 

1.01

 

Tumor site

  

<0.001*

 

0.76

 

0.758

 Coecum

17

0.98

 

1.22

 

1.16

 

 Colon ascendens

14

1.11

 

0.88

 

0.78

 

 Right colon flexure

6

1.28

 

1.32

 

1.13

 

 Colon transversum

3

1.37

 

0.86

 

1.0

 

 Colon descendens

5

2.12

 

2.16

 

1.29

 

 Colon sigmoideum

30

0.96

 

0.99

 

1.14

 
  1. *In ANOVA p < 0.001, the post-hoc Tukey’s test showed a significant difference between colon descendens and coecum, colon ascendens and right colon flexure (p < 0.001; p < 0.001; p = 0.007, respectively)