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Table 3 Correlation between loss of heterozygosity of chromosome 9p and various tumour characteristics in clinically localized renal cell carcinoma

From: Microsatellite alteration and immunohistochemical expression profile of chromosome 9p21 in patients with sporadic renal cell carcinoma following surgical resection

   D9S916 D9S974 D9S942 D9S1814 D9S171
Variables   Normal LOH p= Normal LOH p= Normal LOH p= Normal LOH p= Normal LOH p=
Tumour size Mean 5.3 4.6 0.93 4.8 6.4 0.76 4.8 6.4 0.17 4.8 6.4 0.77 5.1 5.3 0.66
  SD (±3.2) (±2.1)   (±2.9) (±3.4)   (±2.9) (±3.4)   (±2.9) (±3.4)   (±3.2) (±2)  
T stage pT1 20 4 0.005 28 2 0.004 29 2 0.003 19 0 0.028 22 5 0.42
pT2 12 0 7 1 11 0 8 0 12 0
pT3 9 5 13 5 13 6 7 3 12 5
pT4 0 2 0 2 0 1 1 0 0 1
pT1/2 32 4 0.02 35 3 0.02 40 2 0.004 27 0 0.02 34 5 0.084
pT3/4 9 7 13 7 13 7 8 3 12 6
Metastasis N0M0 38 8 0.1 46 6 0.006 50 5 0.006 33 2 0.224 42 8 0.12
N + M+ 3 3 2 4 3 4 2 1 4 3
Fuhrman Grade G1/G2 16 4 1 18 2 0.47 20 2 0.47 14 1 1 18 3 0.73
G3/G4 25 7 30 8 33 7 21 2 28 8
Tumour necrosis Present 10 3 1 14 3 1 16 1 0.42 10 0 0.55 14 3 1
Absent 29 7 33 6 35 7 23 3 30 7
Sarcomatoid change Present 1 3 0.02 2 2 0.12 4 1 0.53 4 1 0.37 3 2 0.23
Absent 38 7 45 7 47 7 29 2 41 8
Microvascular invasion Present 10 2 1 11 3 0.68 13 3 0.67 9 1 1 12 3 1
Absent 28 8 36 6 38 5 23 2 31 7
Renal Vein invasion Present 6 2 1 8 2 0.67 8 2 0.62 3 1 0.32 7 2 1
Absent 31 8 37 7 41 6 28 2 34 8
Pelvicalyceal invasion Present 4 0 0.56 6 1 1 6 1 1 2 1 0.25 7 0 0.32
Absent 33 10 39 8 43 7 29 2 34 10
Renal sinus invasion Present 3 4 0.03 5 4 0.03 5 4 0.016 3 2 0.068 5 4 0.06
Absent 34 6 40 5 44 4 23 1 36 6
SSIGN score 0–2 17 5 0.16 21 3 0.26 22 2 0.29 16 1 0.011 17 4 0.43
S – Stage 03–Apr 4 0 7 0 6 1 4 0 4 0
SI – Size 05–Jun 11 1 9 2 11 2 3 1 10 3
G – Grade 07–Sep 4 2 6 2 8 1 8 0 8 1
N - Necrosis ≥10 1 2 2 2 2 2 0 1 2 2
  1. Numbers in columns under normal and LOH represent number of patients