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Table 2 Clinical course of patients with delayed surgery (> 3 months after diagnosis) (n = 22)

From: Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed

Age at diagnosis Tumor localization Tumor volume Extent of primary surgery Histology Chemotherapy Time from diagnosis to delayed surgery Extent of secondary surgery Current status Reason for delayed surgery
18 mo – 5 yrs Pelvic 179 ml Macroscopic residuals GN mature None 32 mo Complete resection CR Suspected Progression
11 – 18 yrs Pelvic 680 ml Macroscopic residuals GN maturing None 8 mo Macroscopic residuals PR Progression before delayed surgery
11 – 18 yrs Abdominal n.a. Biopsy GN maturing None 4 mo Complete resection CR Planned surgery
5 – 11 yrs Thoracic n.a. Macroscopic residuals GN maturing None 4 mo Macroscopic residual PR Planned surgery
5 – 11 yrs Thoracic 168 ml Macroscopic residuals GN maturing None 6 mo Macroscopic residuals LFU First surgery not in Germany
5 – 11 yrs Abdominal 20 ml Biopsy GN maturing None 9 mo Near -complete resection CR Suspected Progression
5 – 11 yrs Abdominal 120 ml Macroscopic residuals GN maturing 2 cycles 4 mo Macroscopic residual VGPR No response to chemotherapy
5 – 11 yrs Adrenal 56 ml Macroscopic residuals GN maturing None 5 mo Macroscopic residuals VGPR Planned surgery
18 mo – 5 yrs Abdominal 90 ml Biopsy GN maturing None 47 mo Macroscopic residuals VGPR Progression before delayed surgery
18 mo – 5 yrs Abdominal 282 ml Biopsy GN maturing None 9 mo Complete resection CR Suspected Progression
18 mo – 5 yrs Thoracic 16 ml Biopsy GN maturing None 6 mo Macroscopic residual VGPR Suspected Progression
0 – 18 mo Thoracic 26 ml Biopsy GN maturing None 21 mo Macroscopic residuals PR Suspected Progression
18 – 21 yrs Abdominal 72 ml Macroscopic residuals GNBI 4 cycles 11 mo Biopsy VGPR No response to chemotherapy
5 – 11 yrs Thoracic 11 ml Biopsy GNBI None 4 mo Near -complete resection CR No regression during observation
5 – 11 yrs Adrenal 44 ml Macroscopic residuals GNBI 4 cycles 5 mo Near -complete resection CR No response to chemotherapy
5 – 11 yrs Thoracic 42 ml Biopsy GNBI None 11 mo Complete resection CR Suspected Progression
18 mo – 5 yrs Adrenal 150 ml Biopsy GNBI 4 cycles 6 mo Complete resection CR No response to chemotherapy
18 mo – 5 yrs Cervical 87 ml Biopsy GNBI 4 cycles 5 mo Macroscopic residual VGPR No response to chemotherapy
18 mo – 5 yrs Thoracic n.a. Macroscopic residuals GNBI 9 cycles (+MT +RA) 17 mo Macroscopic residual PR Clinical progression
3 months after diagnosis/No response to chemotherapy
18 mo – 5 yrs Abdominal 240 ml Biopsy GNBI 6 cycles (+MT +RA) 7 mo Near -complete resection CR No response to chemotherapy
18 mo – 5 yrs Thoracic 39 ml Biopsy GNBI 7 cycles 4 mo
10 mo
81 mo
Macroscopic residual / Macroscopic residual / Biopsy PD No response to chemotherapy/ Progression before surgery
18 mo – 5 yrs Pelvic 98 ml Macroscopic residuals GNBI None 22 mo Macroscopic residual VGPR Suspected Progression
  1. GNBI = ganglioneuroblastoma intermixed, GN = ganglioneuroma, n.a. = data not available, yrs = years, mo = months, MT = maintenance therapy, RA = retinoic acid,
  2. CR = complete remission, VGPR = very good partial response, PR = partial response, SD = stable disease, PD = progressive disease, LFU = lost to follow-up