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Table 3 Prognostic factors: Univariate and Multivariate analysis

From: Clinical outcomes and prognostic factors of cyberknife stereotactic body radiation therapy for unresectable hepatocellular carcinoma

Parameter Overall survival In-field recurrence free Out-field recurrence free
UA MA UA MA UA MA
  HR (95%CI) P   HR (95%CI) P   HR(95%CI) P
M vs F 0.531 NS 0.377 NS 0.150 NS
Age (y.o)
<60 vs 60 0.217 NS 0.552 NS 0.195 NS
ECOG
 0 vs 1 0.052 NS 0.439 NS 0.910 NS
 0 vs 2 0.234 NS    0.620 NS
AJCC Stage (7th )
 1 vs 2 0.584 NS 0.833 0.974 (0.054-17.559) 0.986 0.380 0.955(0.281-3.251) 0.941
 1 vs 3a 0.058 NS 0.240 1.189 (0.108-13.124) 0.888 0.010 1.684(0.540-5.253) 0.369
 1 vs 3b 0.001 NS 0.021 5.179 (0.320-83.713) 0.247 0.009 1.549(0.495-4.847) 0.452
 1 vs 4 0.063 NS 0.396 0.730 (0.053-10.142) 0.815 0.506 0.841(0.228-3.099) 0.795
BCLC
 A vs B 0.502 NS    0.066 NS
 B vs C 0.077 NS    0.092 NS
Portal Vein Tumor Thrombosis
 N vs Y <0.001 1.774 (1.037-3.036) 0.036 0.035 0.976 (0.167-5694) 0.978 0.054 NS
Child Pugh score
 A vs B 0.001 3.183 (1.397-7.255) 0.006    0.221 NS
Hepatitis virus
 B vs C 0.766 NS 0.663 NS   
 B vs Non B/C 0.766 NS 0.57 NS   
 B vs B + C 0.225 NS     
Albumin (g/dl)
 ≥3.5 vs <3.5 0.033 NS 0.099 NS   
Alkaline Phospatase (IU/L)
≥129 vs < 129 0.895 NS 0.999 NS 0.405 NS
Platelet (10^3/uL)
 ≥150 vs <150 0.302 NS 0.847 NS 0.441 NS
BED
72 vs 73-88 0.980 NS    0.808 0.944 (0.316-2.823) 0.918
72 vs ≥89 0.016 NS 0.052 NS 0.003 0.423 (0.201-0.890) 0.023
Tumor Size (cm)
4 vs >4-9 0.428 2.665 (1.437-4.946) 0.002 0.027 9.210 (1.095-77.473) 0.041 0.872 NS
4 vs 10 0.085 4.928 (1.794-13.546) 0.002 0.034 6.371 (0.630-64.451) 0.117 0.141 NS
Tumor Type
 Solitary vs Multicentric 0.003 NS 0.042 4.173 (0.790-22.044) 0.093 0.003 2.084 (0.880-4.933) 0.095
 Solitary vs Diffuse <0.001 NS 0.243 4.994 (0.338-73.688) 0.242 0.674 0.973 (0.186-5.094) 0.974
Location
 R vs L 0.903 NS 0.816 NS 0.722 1.231 (0.528-2.872) 0.631
 R vs R/L 0.257 NS 0.074 NS 0.006 2.545 (1.038-6.238) 0.041
AFP (ng/ml)
20 vs 20-400 0.005 NS 0.070 NS 0.360 NS
 ≤20vs ≥400 0.066 NS 0.117 NS 0.985 NS
Previous treatment
 No vs Yes 0.592 NS 0.318 NS 0.821 NS
  1. Abbreviations as in Table 1
  2. a. Identify the predictors significant at p-value < 0.2. b. The effects met the 0.1 level for forward and backward method entry into the multivariate survival model based on Collett’s model selection approach. c. p-value of <0.05 was significant