Table 2 Univariate analysis of risk factors affecting patient survival

Total

41.9 ± 32.4

Patient-related

Gender

 Male

41.0 ± 32.1

1

 Female

44.4 ± 33.0

0. 87 (0.73–1.03)

0.1074

Age (years)

 <40

47.1 ± 32.4

1

 40–65

42.4 ± 32.7

1.15 (0.83–1.60)

0.4107

 ≥ 65

39.6 ± 31.6

1.32 (0.94–1.87)

0.1123

Body mass index (kg/m²)

 <18.5

42.1 ± 33.5

1

 18.5–20

36.5 ± 29.2

1.13 (0.86–1.49)

0.3774

 20–24

42.5 ± 30.9

0.91 (0.75–1.10)

0.3137

 ≥ 24

42.8 ± 32.1

0.95 (0.77–1.17)

0.6183

Comorbidity

 No

41.6 ± 32.1

1

 Yes

43.9 ± 34.6

0.93 (0.72–1.21)

0.5909

Family history

 No

41.3 ± 32.5

1

 Yes

44.4 ± 32.0

0.80 (0.66–0.98)

0.0286

Fibrinogen (g/L)

 ≤ 4

45.7 ± 32.6

1

 >4

30.8 ± 28.9

1.78 (1.49–2.11)

< 0.0001

Carcinoembryonic antigen

 <5

43.4 ± 29.3

1

 ≥ 5

31.7 ± 29.1

1.82 (1.38–2.38)

< 0.0001

Carbohydrate antigen 19-9

 <37

43.2 ± 32.6

1

 ≥ 37

26.4 ± 24.6

1.84 (1.44–2.35)

< 0.0001

Tumor-related

Tumor location

 Lower

47.4 ± 32.7

1

 Upper

34.2 ± 30.3

1.83 (1.50–2.23)

< 0.0001

 Medium

30.7 ± 28.7

2.03 (1.70–2.42)

< 0.0001

Tumor size (cm)

 <5

58.5 ± 30.0

1

 ≥ 5

31.5 ± 29.4

3.29 (2.75–3.94)

< 0.0001

Multi-organ involvement

 No

42.7 ± 32.3

1

 Yes

24.3 ± 28.5

2.27 (1.68–3.07)

< 0.0001

Multifocal

 No

44.4 ± 32.0

1

 Yes

55.8 ± 28.5

0.67 (0.38–1.19)

0.1721

Gross morphology

 Flat

34.0 ± 36.0

1

 Uplift

47.4 ± 33.1

0.56 (0.41–0.76)

0.0003

 Ulcerative

55.0 ± 32.3

0.42 (0.31–0.59)

< 0.0001

 Infiltration ulcerative

40.8 ± 30.8

0.71 (0.57–0.90)

0.0037

 Diffuse infiltration

30.4 ± 29.1

1.09 (0.77–1.55)

0.6112

T stage

 1

44.8 ± 37.0

1

 2

64.1 ± 27.4

0.35 (0.25–0.51)

< 0.0001

 3

41.2 ± 30.4

1.20 (0.94–1.52)

0.1397

 4

31.7 ± 28.8

1.80 (1.42–2.27)

< 0.0001

N stage

 N0

52.6 ± 33.4

1

 N1

53.0 ± 31.2

1.12 (0.87–1.45)

0.3837

 N2

35.6 ± 29.7

2.36 (1.91–2.92)

< 0.0001

 N3

23.8 ± 23.0

3.72 (3.06–4.53)

< 0.0001

Metastasis

 No

44.1 ± 32.2

1

 Yes

8.7 ± 7.7

5.75 (4.48–7.38)

< 0.0001

TNM

 1

70.2 ± 25.2

1

 2

56.4 ± 29.6

4.45 (2.80–7.07)

< 0.0001

 3

28.6 ± 26.5

15.14 (9.76–23.49)

< 0.0001

 4

8.8 ± 7.7

50.32 (30.71–82.46)

< 0.0001

Differentiation

 Poor

33.0 ± 31.1

1

 Medium

55.0 ± 30.3

0.38 (0.30–0.48)

< 0.0001

 Signet ring

47.5 ± 30.5

0.49 (0.30–0.82)

0.0058

 Mucus

49.8 ± 31.5

0.58 (0.39–0.86)

0.0064

 Papillary

45.1 ± 32.6

0.54 (0.20–1.44)

0.2174

 Mixed or other

44.0 ± 32.2

0.64 (0.53–0.76)

< 0.0001

Operation-related

Operation time (min.)

 ≤ 150

43.3 ± 32.9

1

 >150

40.3 ± 31.8

1.17 (1.01–1.36)

0.0361

 Radical

52.2 ± 30.8

1

 Non-radical

18.8 ± 20.4

4.74 (4.00–5.62)

< 0.0001

 Palliative

7.2 ± 6.8

12.21 (9.52–15.67)

< 0.0001

Cleared lymph node number

 <15

40.5 ± 33.2

1

 ≥ 15

43.6 ± 31.3

0.81 (0.70–0.95)

0.0072

 ≤ 200

44.1 ± 32.6

1

 >200

31.7 ± 29.4

1.61 (1.35–1.93)

< 0.0001

Blood transfusion

 No

44.6 ± 32.3

1

 Yes

33.4 ± 31.0

1.64 (1.39–1.93)

< 0.0001