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Table 2 CDX2 expression in relation to molecular characteristics in CRC

From: SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

 

CDX2 expression

 
 

<5 %

5–50 %

>50 %

P valuea

Frequencies, n (%)

62 (14.4)

125 (29.0)

244 (56.6)

 

MSI screening status, n (%)b

   

<0.001

 MSI

27 (41.5)

14 (21.5)

24 (36.9)

 

 MSS

33 (9.4)

108 (30.8)

210 (59.8)

 

CIMP status, n (%)b

   

<0.001

 CIMP-negativec

8 (3.8)

66 (31.1)

138 (65.1)

 

 CIMP-lowc

25 (15.6)

46 (28.8)

89 (55.6)

 

 CIMP-highc

29 (52.7)

10 (18.2)

16 (29.1)

 

BRAF V600E, n (%)b

   

<0.001

 wild type

27 (7.4)

110 (30.3)

226 (62.3)

 

 mutated

35 (58.3)

11 (18.3)

14 (23.3)

 

KRAS (codon 12, 13), n (%)b

   

0.027

 wild type

55 (16.2)

88 (26.0)

196 (57.8)

 

 mutated

7 (8.2)

33 (38.8)

45 (52.9)

 

SOX2 expression, n (%)b

   

<0.001

 SOX2 negative

44 (12.3)

100 (27.9)

215 (59.9)

 

 SOX2 positive

15 (32.6)

19 (41.3)

12 (26.1)

 
  1. Abbreviations: MSI microsatellite instability, MSS, microsatellite stable, CIMP CpG island methylator phenotype (according to an eight-gene CIMP panel)
  2. aχ2 test
  3. bThe following numbers of missing cases were present: MSI screening status, 15; CIMP status, 4; BRAF V600E, 8; KRAS, 7; SOX2 expression, 26
  4. cCIMP negative, no promoter hypermethylation; CIMP low, one to five genes methylated; CIMP high, six to eight genes methylated