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Table 2 CDX2 expression in relation to molecular characteristics in CRC

From: SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer

  CDX2 expression  
  <5 % 5–50 % >50 % P valuea
Frequencies, n (%) 62 (14.4) 125 (29.0) 244 (56.6)  
MSI screening status, n (%)b     <0.001
 MSI 27 (41.5) 14 (21.5) 24 (36.9)  
 MSS 33 (9.4) 108 (30.8) 210 (59.8)  
CIMP status, n (%)b     <0.001
 CIMP-negativec 8 (3.8) 66 (31.1) 138 (65.1)  
 CIMP-lowc 25 (15.6) 46 (28.8) 89 (55.6)  
 CIMP-highc 29 (52.7) 10 (18.2) 16 (29.1)  
BRAF V600E, n (%)b     <0.001
 wild type 27 (7.4) 110 (30.3) 226 (62.3)  
 mutated 35 (58.3) 11 (18.3) 14 (23.3)  
KRAS (codon 12, 13), n (%)b     0.027
 wild type 55 (16.2) 88 (26.0) 196 (57.8)  
 mutated 7 (8.2) 33 (38.8) 45 (52.9)  
SOX2 expression, n (%)b     <0.001
 SOX2 negative 44 (12.3) 100 (27.9) 215 (59.9)  
 SOX2 positive 15 (32.6) 19 (41.3) 12 (26.1)  
  1. Abbreviations: MSI microsatellite instability, MSS, microsatellite stable, CIMP CpG island methylator phenotype (according to an eight-gene CIMP panel)
  2. aχ2 test
  3. bThe following numbers of missing cases were present: MSI screening status, 15; CIMP status, 4; BRAF V600E, 8; KRAS, 7; SOX2 expression, 26
  4. cCIMP negative, no promoter hypermethylation; CIMP low, one to five genes methylated; CIMP high, six to eight genes methylated