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Table 2 Plasma pharmacokinetic parameters of MCHB and CNOB in mice carrying 4T1/HchrR6 tumors. Plasma samples were collected at various times (5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, 12 h, and 24 h) after iv dose of CNOB in nude mice carrying 4T1/HchrR6 tumors. MCHB and CNOB levels overtime were determined by LC/MS/MS

From: Utilizing native fluorescence imaging, modeling and simulation to examine pharmacokinetics and therapeutic regimen of a novel anticancer prodrug

CNOB Dose Analyte Cmax ± SE AUC0-24 ± SE Vss CL t1/2
mg/kg   ng/mL h*ng/mL L/kg L/h/kg h
3.3 CNOB 141 ± 28.6 166 ± 23.5 81.5 17.7 4.6
  MCHB 145 ± 30.4 148 ± 16.0 117 21.1 8.3
  1. C max maximum observed concentration ± standard error (SE), AUC 0-24 area under the concentration curve from 0 to 24 h ± SE, V ss volume of distribution, CL clearance; t 1/2 terminal elimination half-life