Fig. 7
Simulation of CNOB dose administrations and predicted tumor growth inhibition. Based on the PK parameters estimates from noncompartmental analysis of single (3.3 mg/kg) dose of CNOB, and tumor growth data (Fig. 6), a combined PK/PD model was constructed which included a 2 compartment iv model linked with an inhibitory Emax model. Simulation predicted plasma CNOB concentrations (a) and corresponding tumor growth curves (b) after the indicated daily doses of CNOB. Circles represent original tumor burden data from Fig. 6