|
Variable
|
No. of deaths/No. of participants
|
Crude HR
|
95 % CI
|
aHRa
|
95 % CI
|
|---|
|
EORTC-QCQ -C30
|
Physical functioning
|
>33.33
|
87/783
|
1
| | |
1
| | |
| | |
≤33.33
|
9/26
|
3.71
|
1.87
|
7.36
|
3.44
|
1.72
|
6.88
|
| |
Role functioning
|
>33.33
|
89/782
|
1
| | |
1
| | |
| | |
≤33.33
|
7/27
|
2.51
|
1.16
|
5.41
|
2.14
|
0.99
|
4.65
|
| |
Emotional functioning
|
>33.33
|
92/792
|
1
| | |
1
| | |
| | |
≤33.33
|
4/17
|
2.12
|
0.78
|
5.77
|
2.59
|
0.94
|
7.14
|
| |
Cognitive functioning
|
>33.33
|
94/793
|
1
| | |
1
| | |
| | |
≤33.33
|
2/16
|
1.08
|
0.27
|
4.37
|
0.95
|
0.23
|
3.90
|
| |
Social functioning
|
>33.33
|
91/786
|
1
| | |
1
| | |
| | |
≤33.33
|
5/23
|
1.99
|
0.81
|
4.88
|
1.56
|
0.63
|
3.88
|
| |
General health status
|
>33.33
|
89/770
|
1
| | |
1
| | |
| | |
≤33.33
|
7/39
|
1.62
|
0.75
|
3.49
|
1.35
|
0.62
|
2.93
|
| |
Fatigue
|
<66.66
|
83/720
|
1
| | |
1
| | |
| | |
≥66.66
|
13/89
|
1.30
|
0.72
|
2.33
|
1.24
|
0.69
|
2.24
|
| |
Nausea & vomiting
|
<66.66
|
94/790
|
1
| | |
1
| | |
| | |
≥66.66
|
2/19
|
0.91
|
0.23
|
3.73
|
0.82
|
0.20
|
3.33
|
| |
Pain
|
<66.66
|
87/752
|
1
| | |
1
| | |
| | |
≥66.66
|
9/57
|
1.41
|
0.71
|
2.80
|
1.28
|
0.61
|
2.66
|
| |
Dyspnea
|
<66.66
|
53/591
|
1
| | |
1
| | |
| | |
≥66.66
|
43/218
|
2.33
|
1.56
|
3.48
|
1.96
|
1.30
|
2.95
|
| |
Insomnia
|
<66.66
|
79/689
|
1
| | |
1
| | |
| | |
≥66.66
|
17/120
|
1.24
|
0.73
|
2.09
|
1.27
|
0.75
|
2.16
|
| |
Appetite loss
|
<66.66
|
76/717
|
1
| | |
1
| | |
| | |
≥66.66
|
20/92
|
2.20
|
1.35
|
3.61
|
1.68
|
1.00
|
2.82
|
| |
Constipation
|
<66.66
|
87/746
|
1
| | |
1
| | |
| | |
≥66.66
|
9/63
|
1.24
|
0.63
|
2.47
|
1.13
|
0.57
|
2.27
|
| |
Diarrhea
|
<66.66
|
88/773
|
1
| | |
1
| | |
| | |
≥66.66
|
8/36
|
2.13
|
1.03
|
4.39
|
2.11
|
1.01
|
4.40
|
| |
Financial difficulties
|
<66.66
|
77/686
|
1
| | |
1
| | |
| | |
≥66.66
|
19/123
|
1.39
|
0.84
|
2.30
|
1.14
|
0.68
|
1.89
|
|
EORTC-QCQ -LC13
|
Dyspnea
|
<66.66
|
77/733
|
1
| | |
1
| | |
| | |
≥66.66
|
19/76
|
2.62
|
1.59
|
4.33
|
2.26
|
1.36
|
3.76
|
| |
Coughing
|
<66.66
|
77/726
|
1
| | |
1
| | |
| | |
≥66.66
|
19/83
|
2.35
|
1.42
|
3.88
|
1.92
|
1.15
|
3.20
|
| |
Hemoptysis
|
<66.66
|
95/803
|
1
| | |
1
| | |
| | |
≥66.66
|
1/6
|
1.35
|
0.19
|
9.67
|
0.82
|
0.11
|
5.94
|
| |
Sore mouth
|
<66.66
|
90/782
|
1
| | |
1
| | |
| | |
≥66.66
|
6/26
|
2.15
|
0.94
|
4.91
|
1.83
|
0.80
|
4.19
|
| |
Dysphagia
|
<66.66
|
90/783
|
1
| | |
1
| | |
| | |
≥66.66
|
6/26
|
2.18
|
0.96
|
4.99
|
1.62
|
0.70
|
3.74
|
| |
Peripheral neuropathy
|
<66.66
|
84/725
|
1
| | |
1
| | |
| | |
≥66.66
|
12/84
|
1.28
|
0.70
|
2.35
|
1.29
|
0.70
|
2.37
|
| |
Alopecia
|
<66.66
|
89/756
|
1
| | |
1
| | |
| | |
≥66.66
|
7/52
|
1.17
|
0.54
|
2.53
|
1.26
|
0.58
|
2.74
|
| |
Pain in chest
|
<66.66
|
80/727
|
1
| | |
1
| | |
| | |
≥66.66
|
16/82
|
1.85
|
1.08
|
3.16
|
1.70
|
0.98
|
2.95
|
| |
Pain in arm or shoulder
|
<66.66
|
82/699
|
1
| | |
1
| | |
| | |
≥66.66
|
14/110
|
1.09
|
0.62
|
1.93
|
1.22
|
0.69
|
2.15
|
| |
Pain in other body parts
|
<66.66
|
83/726
|
1
| | |
1
| | |
| | |
≥66.66
|
12/82
|
1.32
|
0.72
|
2.43
|
1.44
|
0.78
|
2.65
|
- Abbreviations: HR hazard ratio, aHR adjusted hazard ratio, CI confidence interval
- aEach of the multiple proportional hazard regression analysis was adjusted for age, sex, stage, BMI at the time of survey, and MET
