The effects of lymph node status on predicting outcome in ER+ /HER2- tamoxifen treated breast cancer patients using gene signatures

Table 7 Gene Sets enriched in lymph node positive patients

LN+	Gene Set Name	Inferred Biological Activity	Genes Represented	ES
Long Term Remission	SMID_BREAST_CANCER_NORMAL_LIKE_UP		420	0.65
	WIELAND_UP_BY_HBV_INFECTION	Immune	91	0.77
	WALLACE_PROSTATE_CANCER_RACE_UP	Increased Risk	259	0.66
	MCLACHLAN_DENTAL_CARIES_UP	Immune	225	0.59
	KIM_LRRC3B_TARGETS	Immune	28	0.85
	FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP	Immune	78	0.67
	VANTVEER_BREAST_CANCER_ESR1_DN	ER down	197	0.59
	TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN		144	0.60
	ICHIBA_GRAFT_VERSUS_HOST_DISEASE_D7_UP	Immune	89	0.66
	LEE_DIFFERENTIATING_T_LYMPHOCYTE	Immune	138	0.61
Distant Metastasis	NIKOLSKY_BREAST_CANCER_8Q12_Q22_AMPLICON		86	−0.68
	NIKOLSKY_BREAST_CANCER_8Q23_Q24_AMPLICON		83	−0.66
	ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE	EMT	60	−0.70
	TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_UP		28	−0.65
	FARMER_BREAST_CANCER_CLUSTER_5		18	−0.74
	TURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP		52	−0.55
	MILI_PSEUDOPODIA_HAPTOTAXIS_UP	Migration	348	−0.41
	DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER	CNVs	81	−0.49
	IIZUKA_LIVER_CANCER_PROGRESSION_G2_G3_UP	Differentiation	24	−0.64
	HAMAI_APOPTOSIS_VIA_TRAIL_UP	Apoptosis	463	−0.38

ISSN: 1471-2407