The effects of lymph node status on predicting outcome in ER+ /HER2- tamoxifen treated breast cancer patients using gene signatures

Table 6 Gene sets enriched in lymph node negative patients

LN-	Gene Set Name	Inferred Biological Activity	Genes Represented	ES
Long Term Remission	SHEN_SMARCA2_TARGETS_UP	Epigenetic	347	0.65
	SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP		321	0.60
	BOQUEST_STEM_CELL_UP	Stemness	239	0.57
	ANASTASSIOU_CANCER_MESENCHYMAL_TRANSITION_SIGNATURE	EMT	60	0.71
	SMID_BREAST_CANCER_LUMINAL_A_UP		78	0.67
	PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP	Immune	171	0.58
	TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_DN		52	0.71
	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	Radiation	409	0.52
	FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP	Immune	480	0.51
	REN_ALVEOLAR_RHABDOMYOSARCOMA_DN	PAX3-FOXO1 down	386	0.52
Distant Metastasis	SHEN_SMARCA2_TARGETS_DN	Epigenetic	312	−0.54
	RICKMAN_HEAD_AND_NECK_CANCER_F		47	−0.72
	SOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_UP		130	−0.54
	ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER	Proliferation	124	−0.51
	KEGG_OLFACTORY_TRANSDUCTION	Signalling	66	−0.58
	REACTOME_STRIATED_MUSCLE_CONTRACTION		27	−0.70
	KUNINGER_IGF1_VS_PDGFB_TARGETS_UP	IGF	58	−0.58
	XU_HGF_TARGETS_REPRESSED_BY_AKT1_DN	AKT/HGF	81	−0.51
	MIKKELSEN_MEF_ICP_WITH_H3K27ME3	Epigenetic	118	−0.48
	MIKKELSEN_MCV6_LCP_WITH_H3K27ME3	Epigenetic	15	−0.76

ISSN: 1471-2407