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Fig. 6 | BMC Cancer

Fig. 6

From: The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer

Fig. 6

Metastatic lesion formation is inhibited by MRx102 treatment. a Representative whole organ imaging and H&E tissue staining of NSG mice injected with H460 (top grouping) and A549 (bottom grouping) cells. Lung (left) and liver (right) images with corresponding pathological analyses. In each H&E stain grouping top-left – control (PBS) treatment at 5x magnification, bottom-left - control (PBS) treatment at 20x magnification, top-right – MRx102 (3 mg/kg) treatment at 5x magnification, and bottom-right – MRx102 (3 mg/kg) treatment at 20x magnification. b Quantification of H460 (left grouping) and A549 (right grouping) metastatic colony formation in lung (left) and liver (right) from tail-vein injected NSG mice. n = 8 mice, *, **, and *** represents p values of < .05, <.01, and <0.001 as determined by a Student t-test

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