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Fig. 1 | BMC Cancer

Fig. 1

From: The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer

Fig. 1

MRx102 decreases lung cancer cell proliferation and increases apoptosis. a Cell proliferation assay and corresponding quantification of cell number for H460 (top panel) and A549 (bottom panel) cells treated with MRx102 (0-100nM). b Colony formation assay with quantification of colony number for H460 (top) and A549 (bottom) cells treated with MRx102 (0, 1, 3 nM top row and 10, 30, 100nM bottom row). Annexin V/PI staining of H460 (c-left) and A549 (c-right) cells. Quadrants are as follows: Top-left – dead/necrotic cells, Top-right – Late apoptotic cells, Bottom-right – Early apoptotic cells, and Bottom-left – Live cells. d Western blot analysis of p53 expression and Akt activation in H460 and A549 cells. *** represents a p value of <0.001 as determined by a Student T-test

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