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Table 2 Treatment-Related Preoperative Grade 3 or 4 Adverse Events

From: Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer

Adverse Event Grade 3 Grade 4
Hematologic
 Leukopenia 6 (15.0 %) 2 (5.0 %)
 Neutropenia 3 (7.5 %) 2 (5.0 %)
 Anemia requiring blood transfusion 2 (5.0 %)  
 Febrile neutropenia 1 (2.5 %) 2 (5.0 %)
 Thrombocytopenia   1 (2.5 %)
Gastrointestinal
 Dysphagia, esophagitis, odynophagia 7 (17.5 %) 1 (2.5 %)
 Anorexia 7 (17.5 %)  
 Dehydration 7 (17.5 %)  
 Nausea 6 (15.0 %)  
 Diarrhea 4 (10.0 %)  
 Vomiting 4 (10.0 %)  
 Abdominal pain or cramping 2 (5.0 %)  
Systemic
 Fatigue 3 (7.5 %)  
 Hypotension 3 (7.5 %) 1 (2.5 %)
 Hyperbilirubinemia 1 (2.5 %)  
 Creatinine Elevation 1 (2.5 %)  
 Chest pain (non-cardiac) 1 (2.5 %)  
 Supraventricular arrhythmia 1 (2.5 %)  
 Syncope 1 (2.5 %)  
 Thrombosis/embolism   1 (2.5 %)