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Table 5 Survival under specific treatments

From: Osteopontin splice variants are differential predictors of breast cancer treatment responses

   Exon 4 intensity Exon 4 % OPN-c intensity OPN-c %
Treatment n Odds ratio 95 % CI p-value Supre-mum test Odds ratio 95 % CI p-value Supre-mum test Odds ratio 95 % CI p-value Supre-mum test Odds ratio 95 % CI p-value Supre-mum test
hormone no (all subgroups) 54 0.503 0.287-0.881 0.016 0.104 1.087 0.624-1.895 0.767 0.908 0.620 0.353-1.089 0.096 0.178 1.210 0.696-2.102 0.500 0.954
hormone yes (all subgroups) 65 0.657 0.381-1.134 0.131 <.0001 0.687 0.391-1.206 0.191 0.056 0.826 0.463-1.473 0.517 0.005 1.101 0.630-1.923 0.735 0.704
hormone alone 18 1.534 0.430-5.467 0.509 0.614 1.122 0.420-2.998 0.819 0.616 1.661 0.607-4.542 0.323 0.518 1.113 0.383-3.235 0.845 0.607
hormone and chemo 16 0.412 0.129-1.316 0.134 0.022 0.637 0.173-2.343 0.497 0.064 0.634 0.204-1.973 0.432 0.049 1.352 0.441-4.148 0.598 0.269
hormone and radiation 10 0.358 0.069-1.862 0.222 0.180 0.495 0.096-2.558 0.401 0.568 0.250 0.029-2.180 0.209 0.185 0.827 0.192-3.561 0.798 0.597
hormone, chemo, radiation 21 0.598 0.169-2.112 0.424 0.763 0.604 0.218-1.676 0.333 0.801 0.867 0.278-2.710 0.806 0.375 0.894 0.310-2.580 0.836 0.810
chemo no (all subgroups) 30 0.711 0.320-1.580 0.403 0.025 0.794 0.366-1.722 0.560 0.233 0.903 0.391-2.084 0.811 0.134 0.978 0.425-2.254 0.959 0.612
chemo yes (all subgroups) 89 0.582 0.371-0.913 0.019 0.001 0.873 0.552-1.383 0.564 0.520 0.694 0.439-1.098 0.119 0.003 1.181 0.754-1.848 0.468 0.327
chemo (CMF) 55 0.524 0.290- 0.943 0.031 0.008 0.727 0.403-1.314 0.291 0.693 0.706 0.391-1.276 0.249 0.013 1.113 0.626-1.979 0.715 0.337
chemo (AC/CMF) 34 0.688 0.338-1.400 0.302 0.144 1.252 0.596-2.632 0.553 0.543 0.681 0.329-1.410 0.301 0.121 1.280 0.608-2.694 0.515 0.727
chemo alone 13 0.418 0.111-1.574 0.197 0.763 1.207 0.367-3.971 0.757 0.637 0.711 0.205-2.468 0.592 0.047 1.200 0.362-3.980 0.766 0.560
chemo and radiation 39 0.546 0.285-1.047 0.069 0.027 1.343 0.686-2.629 0.389 0.449 0.623 0.320-1.213 0.164 0.444 1.215 0.641-2.304 0.551 0.950
radiation no (all subgroups) 47 0.647 0.333-1.259 0.200 0.024 0.973 0.519-1.824 0.933 0.203 0.981 0.527-1.826 0.951 0.105 1.400 0.746-2.627 0.294 0.404
radiation yes (all subgroups) 72 0.626 0.376-1.044 0.073 0.002 0.774 0.466-1.285 0.321 0.489 0.675 0.394-1.157 0.153 0.036 1.086 0.659-1.791 0.745 0.832
  1. Cox hazard ratios. The immunohistochemistry results for osteopontin-c and exon 4 were categorized into high staining (path scores 2 and 3) or low staining (path scores 0 and 1). Significant p-values are underlined, and confidence intervals that do not contain 1.0 are shown in bold. The last column displays the p-value for the supremum test, which assesses the proportionality assumption. p-values in italics are significant and indicate low confidence in the proportionality