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Table 5 Survival under specific treatments

From: Osteopontin splice variants are differential predictors of breast cancer treatment responses

  

Exon 4 intensity

Exon 4 %

OPN-c intensity

OPN-c %

Treatment

n

Odds ratio

95 % CI

p-value

Supre-mum test

Odds ratio

95 % CI

p-value

Supre-mum test

Odds ratio

95 % CI

p-value

Supre-mum test

Odds ratio

95 % CI

p-value

Supre-mum test

hormone no (all subgroups)

54

0.503

0.287-0.881

0.016

0.104

1.087

0.624-1.895

0.767

0.908

0.620

0.353-1.089

0.096

0.178

1.210

0.696-2.102

0.500

0.954

hormone yes (all subgroups)

65

0.657

0.381-1.134

0.131

<.0001

0.687

0.391-1.206

0.191

0.056

0.826

0.463-1.473

0.517

0.005

1.101

0.630-1.923

0.735

0.704

hormone alone

18

1.534

0.430-5.467

0.509

0.614

1.122

0.420-2.998

0.819

0.616

1.661

0.607-4.542

0.323

0.518

1.113

0.383-3.235

0.845

0.607

hormone and chemo

16

0.412

0.129-1.316

0.134

0.022

0.637

0.173-2.343

0.497

0.064

0.634

0.204-1.973

0.432

0.049

1.352

0.441-4.148

0.598

0.269

hormone and radiation

10

0.358

0.069-1.862

0.222

0.180

0.495

0.096-2.558

0.401

0.568

0.250

0.029-2.180

0.209

0.185

0.827

0.192-3.561

0.798

0.597

hormone, chemo, radiation

21

0.598

0.169-2.112

0.424

0.763

0.604

0.218-1.676

0.333

0.801

0.867

0.278-2.710

0.806

0.375

0.894

0.310-2.580

0.836

0.810

chemo no (all subgroups)

30

0.711

0.320-1.580

0.403

0.025

0.794

0.366-1.722

0.560

0.233

0.903

0.391-2.084

0.811

0.134

0.978

0.425-2.254

0.959

0.612

chemo yes (all subgroups)

89

0.582

0.371-0.913

0.019

0.001

0.873

0.552-1.383

0.564

0.520

0.694

0.439-1.098

0.119

0.003

1.181

0.754-1.848

0.468

0.327

chemo (CMF)

55

0.524

0.290- 0.943

0.031

0.008

0.727

0.403-1.314

0.291

0.693

0.706

0.391-1.276

0.249

0.013

1.113

0.626-1.979

0.715

0.337

chemo (AC/CMF)

34

0.688

0.338-1.400

0.302

0.144

1.252

0.596-2.632

0.553

0.543

0.681

0.329-1.410

0.301

0.121

1.280

0.608-2.694

0.515

0.727

chemo alone

13

0.418

0.111-1.574

0.197

0.763

1.207

0.367-3.971

0.757

0.637

0.711

0.205-2.468

0.592

0.047

1.200

0.362-3.980

0.766

0.560

chemo and radiation

39

0.546

0.285-1.047

0.069

0.027

1.343

0.686-2.629

0.389

0.449

0.623

0.320-1.213

0.164

0.444

1.215

0.641-2.304

0.551

0.950

radiation no (all subgroups)

47

0.647

0.333-1.259

0.200

0.024

0.973

0.519-1.824

0.933

0.203

0.981

0.527-1.826

0.951

0.105

1.400

0.746-2.627

0.294

0.404

radiation yes (all subgroups)

72

0.626

0.376-1.044

0.073

0.002

0.774

0.466-1.285

0.321

0.489

0.675

0.394-1.157

0.153

0.036

1.086

0.659-1.791

0.745

0.832

  1. Cox hazard ratios. The immunohistochemistry results for osteopontin-c and exon 4 were categorized into high staining (path scores 2 and 3) or low staining (path scores 0 and 1). Significant p-values are underlined, and confidence intervals that do not contain 1.0 are shown in bold. The last column displays the p-value for the supremum test, which assesses the proportionality assumption. p-values in italics are significant and indicate low confidence in the proportionality