Time (hrs) | Treatment | Cell cycle distribution (% ± SE) | ||||
---|---|---|---|---|---|---|
Sub-G1 | G1 | S | G2/M | >4 N | ||
24 | (−) | 8.57 ± 0.34 | 57.61 ± 1.07 | 15.48 ± 0.53 | 16.96 ± 0.89 | 0.92 ± 0.21 |
Ad-LacZ | 0.17 ± 0.02 | 58.59 ± 0.71 | 18.33 ± 0.19 | 22.24 ± 0.39 | 1.18 ± 0.17 | |
Ad-delE1B55 | 0.25 ± 0.10 | 59.35 ± 0.68 | 20.28 ± 0.08 | 15.33 ± 0.38 | 5.45 ± 0.19 | |
ZOL | 0.16 ± 0.03 | 61.76 ± 0.64 | 25.71 ± 0.31 | 212.15 ± 0.48 | 0.89 ± 0.05 | |
ZOL + Ad-LacZ | 0.15 ± 0.03 | 67.62 ± 0.48 | 21.85 ± 0.35 | 9.87 ± 0.20 | 0.96 ± 0.07 | |
ZOL + Ad-delE1B55 | 0.23 ± 0.03 | 65.45 ± 0.73 | 17.33 ± 0.21 | 14.21 ± 0.38 | 3.24 ± 0.24 | |
48 | (−) | 2.79 ± 0.15 | 75.8 ± 0.13 | 9.30 ± 0.05 | 13.66 ± 0.20 | 0.93 ± 0.06 |
Ad-LacZ | 0.24 ± 0.01 | 73.42 ± 0.15 | 9.22 ± 0.21 | 16.30 ± 0.20 | 1.08 ± 0.13 | |
Ad-delE1B55 | 1.17 ± 0.05 | 1.70 ± 0.22 | 8.77 ± 0.22 | 36.84 ± 0.12 | 51.80 ± 0.28 | |
ZOL | 0.86 ± 0.10 | 58.00 ± 0.54 | 25.64 ± 0.15 | 15.28 ± 0.27 | 0.82 ± 0.11 | |
ZOL + Ad-LacZ | 0.70 ± 0.03 | 60.80 ± 0.20 | 25.40 ± 0.27 | 12.92 ± 0.28 | 0.77 ± 0.03 | |
ZOL + Ad-delE1B55 | 1.44 ± 0.22 | 19.93 ± 1.20 | 47.98 ± 1.01a | 1.28 ± 0.32 | 0.64 ± 0.37 | |
72 | (−) | 1.06 ± 0.02 | 76.33 ± 0.64 | 9.26 ± 0.23 | 12.68 ± 0.28 | 0.92 ± 0.21 |
Ad-LacZ | 0.51 ± 0.06 | 76.20 ± 0.37 | 8.68 ± 0.26 | 13.50 ± 0.46 | 1.41 ± 0.07 | |
Ad-delE1B55 | 6.67 ± 0.17 | 2.15 ± 0.23 | 5.12 ± 0.49 | 27.45 ± 0.26 | 59.21 ± 0.85 | |
ZOL | 5.67 ± 0.23 | 59.46 ± 0.21 | 19.55 ± 0.57 | 14.86 ± 0.47 | 1.02 ± 0.07 | |
ZOL + Ad-LacZ | 6.07 ± 0.13 | 61.94 ± 0.30 | 16.93 ± 0.16 | 14.56 ± 0.12 | 0.97 ± 0.11 | |
ZOL + Ad-delE1B55 | 8.56 ± 0.38a | 7.77 ± 0.84 | 41.33 ± 1.20a | 22.49 ± 0.42 | 20.77 ± 0.11 |