Time (hrs) | Treatment | Cell cycle distribution (% ± SE) | ||||
---|---|---|---|---|---|---|
Sub-G1 | G1 | S | G2/M | >4 N | ||
24 | (−) | 2.04 ± 0.04 | 58.80 ± 0.20 | 18.17 ± 0.24 | 20.67 ± 0.31 | 0.81 ± 0.06 |
Ad-LacZ | 2.90 ± 0.16 | 57.30 ± 0.19 | 17.59 ± 0.22 | 20.97 ± 0.26 | 1.83 ± 0.04 | |
Ad-delE1B55 | 2.61 ± 0.16 | 55.29 ± 0.07 | 20.41 ± 0.11 | 20.08 ± 0.27 | 2.22 ± 0.11 | |
ZOL | 2.47 ± 0.05 | 57.47 ± 0.10 | 18.34 ± 0.27 | 20.70 ± 0.22 | 1.62 ± 0.09 | |
ZOL + Ad-LacZ | 3.58 ± 0.17 | 55.98 ± 0.16 | 17.94 ± 0.17 | 20.84 ± 0.10 | 2.22 ± 0.08 | |
ZOL + Ad-delE1B55 | 3.72 ± 0.05 | 53.99 ± 0.11 | 20.53 ± 0.23 | 19.42 ± 0.35 | 3.00 ± 0.09 | |
48 | (−) | 1.73 ± 0.07 | 76.54 ± 0.12 | 8.20 ± 0.03 | 12.59 ± 0.08 | 1.18 ± 0.04 |
Ad-LacZ | 1.37 ± 0.08 | 75.90 ± 0.38 | 8.60 ± 0.16 | 12.55 ± 0.33 | 1.82 ± 0.03 | |
Ad-delE1B55 | 12.25 ± 0.04 | 51.87 ± 0.21 | 12.47 ± 0.13 | 21.56 ± 0.19 | 2.32 ± 0.03 | |
ZOL | 3.82 ± 0.08 | 76.77 ± 0.43 | 6.70 ± 0.09 | 11.31 ± 0.33 | 1.60 ± 0.01 | |
ZOL + Ad-LacZ | 2.81 ± 0.11 | 76.08 ± 0.33 | 7.47 ± 0.12 | 11.95 ± 0.13 | 1.96 ± 0.06 | |
ZOL + Ad-delE1B55 | 19.69 ± 0.18a | 47.47 ± 0.19a | 15.42 ± 0.44a | 15.23 ± 0.35 | 2.69 ± 0.16 | |
72 | (−) | 0.96 ± 0.02 | 87.55 ± 0.01 | 3.77 ± 0.13 | 7.26 ± 0.19 | 0.59 ± 0.05 |
Ad-LacZ | 1.46 ± 0.10 | 87.58 ± 0.30 | 2.75 ± 0.05 | 7.79 ± 0.14 | 0.51 ± 0.03 | |
Ad-delE1B55 | 22.52 ± 0.07 | 43.47 ± 0.18 | 11.57 ± 0.14 | 12.89 ± 0.23 | 10.14 ± 0.23 | |
ZOL | 11.19 ± 0.08 | 76.77 ± 0.28 | 3.45 ± 0.08 | 7.93 ± 0.20 | 0.81 ± 0.12 | |
ZOL + Ad-LacZ | 6.44 ± 0.03 | 80.27 ± 0.15 | 3.04 ± 0.04 | 9.66 ± 0.13 | 0.78 ± 0.04 | |
ZOL + Ad-delE1B55 | 35.52 ± 0.05a | 24.06 ± 0.30a | 13.89 ± 0.13b | 11.83 ± 0.21 | 15.41 ± 0.19 | |
96 | (−) | 1.03 ± 0.07 | 87.25 ± 0.01 | 4.43 ± 0.03 | 6.93 ± 0.06 | 0.50 ± 0.03 |
Ad-LacZ | 1.16 ± 0.06 | 87.36 ± 0.28 | 3.34 ± 0.17 | 7.65 ± 0.11 | 0.68 ± 0.04 | |
Ad-delE1B55 | 12.14 ± 0.27 | 53.92 ± 0.29 | 11.93 ± 0.06 | 13.21 ± 0.27 | 9.32 ± 0.31 | |
ZOL | 9.32 ± 0.11 | 80.72 ± 0.21 | 3.98 ± 0.06 | 5.73 ± 0.07 | 0.40 ± 0.07 | |
ZOL + Ad-LacZ | 8.93 ± 0.17 | 78.40 ± 0.17 | 4.22 ± 0.14 | 7.92 ± 0.13 | 0.79 ± 0.04 | |
ZOL+ Ad-delE1B55 | 40.75 ± 0.08a | 21.50 ± 0.21a | 14.26 ± 0.11b | 10.58 ± 0.12 | 13.59 ± 0.18b |