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Fig. 4 | BMC Cancer

Fig. 4

From: Combination of a third generation bisphosphonate and replication-competent adenoviruses augments the cytotoxicity on mesothelioma

Fig. 4

Giemsa staining after Ad-delE1B55 infection. Cells were treated with ZOL (MSTO-211H: 10 μM, NCI-H226: 60 μM, NCI-H28: 80 μM) and/or Ad-delE1B55 (MSTO-211H: 2 × 103 vp/cell, NCI-H226: 1 × 103 vp/cell, NCI-H28: 2 × 103 vp/cell) for 72 h. Nuclear morphological changes were examined after the Giemsa staining. In Ad-delE1B55-treated cells, small and highly condensed nucleus (solid arrow) and large and uncondensed nucleus (open arrow) were detected. An upper panel and lower panel are x4 and x10 in magnifications, respectively

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