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Table 6 Comparison of the radiochemotherapy groups (30–40 mg/m2 of cisplatin weekly vs. 100 mg/m2 of cisplatin on days 1, 22 and 43) for acute and late adverse events

From: Comparison of weekly administration of cisplatin versus three courses of cisplatin 100 mg/m2 for definitive radiochemotherapy of locally advanced head-and-neck cancers

 

Cisplatin weekly N patients (%)

Cisplatin 100 mg/m2 N patients (%)

P

Oral mucositis

 Grade ≥2

70 (93)

55 (95)

0.95

Skin reactions

 Grade ≥2

48 (64)

48 (83)

0.25

Hematotoxicity

 Grade ≥3

7 (9)

19 (33)

0.004

Renal failure

 Grade ≥2

2 (3)

12 (21)

0.004

Pneumonia/Sepsis

 Grade ≥3

1 (1)

7 (12)

0.033

Xerostomiaa

 Grade ≥2

28/60 (47)

34/58 (59)

0.44

Subcutaneous fibrosisa

 Grade ≥2

27/72 (38)

28/51 (55)

0.20

  1. anot available in all patients
  2. After Bonferroni correction for multiple tests (7 tests), p-values of <0.007 were considered significant
  3. Bold values represent significant p-values
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BMC Cancer

ISSN: 1471-2407

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