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Table 2 Suppressed genes in miR-944 transfected cells with roles in cell migration and invasion

From: Suppression of cell migration is promoted by miR-944 through targeting of SIAH1 and PTP4A1 in breast cancer cells

aGene symbol bProtein name Fold change Associated function in cancer miR-944 binding sitesc
NEK2 Serine/threonine-protein kinase Nek2 (Never in mitosis A-related kinase 2) -3.09 Nek2 is up-regulated in pre-invasive in situ ductal and invasive breast carcinomas 0
ADAM28 Disintegrin and metalloproteinase domain-containing protein 28 -3.05 ADAM28 is overexpressed in lymph node metastasis in lung carcinomas 0
PAK1 Serine/threonine-protein kinase p21-activated kinase1 -3.03 PAK1 induces colorectal cancer metastasis by ERK activation and FAK-Ser901 phosphorylation 0
FGFR2 Fibroblast growth factor receptor 2 -3.01 Overexpression of FGFR2, a transforming oncogene in human mammary epithelial cells, leads to invasive phenotype 0
RAC1 Ras-related C3 botulinum toxin substrate 1 -2.98 RAC1 activation mediates Twist1-induced cancer cell migration 0
ANXA7 Annexin A7 -2.67 Decreased ANXA7 expression is associated with high invasive potential in multiple tumors 0
NCOA4 Nuclear receptor coactivator 4 -2.34 NCOA4 (ARA70) promotes cell growth and invasion in prostate cancer 0
MMP14 matrix metallopeptidase 14 -2.3 MMP14 controls invasiveness of aggressive breast tumours, and is associated with clinical outcome 1
PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 -2.23 Promotes mitosis and migration of human breast cancer-derived cells 0
PRKCA Protein kinase C, alpha -1.96 PRKCA regulate Ets1 in invasive breast cancer 1
SIAH1 E3-ubiquitin protein ligase -1.90 Promotes migration and invasion of glioma cells by regulating HIF-1 under hypoxia. Impairs tumor growth and metastasis inbreast cancer 1
PTP4A1 Protein tyrosine phosphatase type IVA, member 1 -1.80 PTP4A1 is related to the lymph node metastasis of colonic adenocarcinoma. Promotes cell motility, invasion and metastasis of ovarian and lung cancer cells. 1
DEK DEK -1.58 DEK oncogene regulates motility and invasion in breast cancer 0
NOTCH2 Neurogenic locus notch homolog protein 2 -1.58 Plays a role in invasive breast cancer 0
TRIM32 E3 ubiquitin-protein ligase TRIM32 (Tripartite motifcontaining 32) -1.53 TRIM32 oncogene promotes tumor growth, metastasis, and resistance to anticancer drugs via degradation of Ablinteractor 2 1
  1. aGenBank databases. bUniprot database (Recommended name). cPredicted by TargetScan