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Fig. 4 | BMC Cancer

Fig. 4

From: Involvement of DNMT 3B promotes epithelial-mesenchymal transition and gene expression profile of invasive head and neck squamous cell carcinomas cell lines

Fig. 4

Involvement of DNA methylation in E-cadherin 5′ region. a Demethylation agent 5′AZA could restored E-cadherin expression on A253-5 cells. b Illustration of CpG islands distribution on 5′ region of E-cadherin. c Methylation specific PCR of E-cadherin in A253 cells. M indicated methylated amplicon and U indicated unmethylated amplicon. MSS1, positive control; WBC: normal human white blood cell for negitive control. d Bissulfite sequence of E-cadherin in A253 cells reveal that knockdown of DNMT 3B could result in demethylation of 5′ region of E-cadherin. *** indicated p < 0.001 as compared with A253-0 and ### indicated p < 0.001 as compared with A253-5

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BMC Cancer

ISSN: 1471-2407

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