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Fig. 5 | BMC Cancer

Fig. 5

From: The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model

Fig. 5

Effect of LTD4 or PGE2 on the levels of different cytokines and eicosanoids in xenograft ALDH+ HCT-116 cell tumor mice. a mRNA expression of cytokines (IL-1β, IL-6 and IL-10) in tumors of mice treated with vehicle, LTD4 or PGE2. b Plasma levels of cytokines (IL-1β, IL-2, IL-6, TNF-α, CXCL1, IL-10 and IFN-γ) from vehicle- (ethanol), LTD4- or PGE2-treated xenograft mice. c Plasma levels of CysLTs and PGE2 from vehicle, LTD4- or PGE2-treated xenograft mice. The results are expressed as means ± SEM, n = 6 mice in each groups. *P < 0.05 and **P < 0.01

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