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Fig. 4 | BMC Cancer

Fig. 4

From: The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model

Fig. 4

FACS and immunohistochemistry analysis of LTD4- or PGE2-treated xenograft mice tumors. a Representative dot plots and corresponding graphs of FACS analysis of the percentage of CD45+ and F4/80+ double positive cells in dissociated tumors from vehicle (ethanol), LTD4 or PGE2 treated groups respectively. b Representative immunohistochemistry images (40×) of F4/80 and their corresponding bar graphs show overall F4/80 scores within tumors. The final scores represent the sum of the staining intensity and staining percentage within the tumor area. c Representative dot plots and corresponding graphs of FACS analysis of the percentage of F4/80+ and CD206+ double positive cells in dissociated tumors from vehicle (ethanol), LTD4 or PGE2 treated groups respectively. d Relative mRNA expression of arginase 1 in tumors of mice treated with LTD4 or PGE2. The analyzed data are expressed as means ± SEM, n = 6 mice in each group. *P < 0.05 and **P < 0.01

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