Fig. 3

Effects of Dp treatment on the expressions of HOTAIR in breast carcinogenesis and in breast cancer cells. a The levels of HOTAIR in MCF10A, CarT and CarT-Dp (40 μM Dp) cells in the cellular breast carcinogenesis model were detected by qRT-PCR. b Effects of Dp treatment for 24 h on the levels of HOTAIR in breast cancer cells MDA-MB-231, MCF-7 and MDA-MB-453. c The effect of Dp administration (40 mg/kg) on the xenografted breast tumors of MDA-MB-231-Luc-GFP cells monitored by in vivo luminescence imaging system. The tumors weight was measured at day 28 post-implantation. d The effect of Dp administration (40 mg/kg) on the level of HOTAIR in xenografted breast tumors. The data are presented as the mean ± SD (n = 3). ^* P < 0.05, ^** P < 0.01 compared with MCF10A cells; ^# P < 0.05, ^## P < 0.01 compared with CarT cells or the control