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Table 1 Relationship between clinicopathologic parameters and MEP1A or E-cadherin protein expression (n = 88)

From: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

Parameters

Total

MEP1A

P

E-cadherin

P

Low37

High51

Low55

High33

Age

       

 <65

31

13

18

 

16

15

 

 ≥65

57

24

33

0.988a

39

18

0.120a

Gender

       

 Male

46

18

28

 

29

17

 

 Female

42

19

23

0.562a

26

16

0.912a

Location

       

 Right

37

15

22

 

21

16

 

 Others

51

22

29

0.808a

34

17

0.343a

Tumor size (cm)

       

 <5

47

25

22

 

31

16

 

 ≥5

41

12

29

0.023*a

24

17

0.473a

AJCC stage

       

 I + II

52

27

25

 

26

26

 

 III + IV

36

10

26

0.024*a

29

7

0.004*a

T stage

       

 T1 + T2

9

7

2

 

6

3

 

 T3 + T4

79

30

49

0.032*b

49

30

1.000b

N stage

       

 N0

54

30

24

 

29

25

 

 N1 + N2

34

7

27

0.001*a

26

8

0.032*a

M stage

       

 M0

86

37

49

 

53

33

 

 M1

2

0

2

0.507b

2

0

0.526b

Differentiation

       

 Well + Moderate

78

35

43

 

51

27

 

 Poor

10

2

8

0.182b

4

6

0.167b

Vascular invasion

       

 No

84

37

47

 

51

33

 

 Yes

4

0

4

0.135b

4

0

0.292b

  1. Immunohistochemistry on tissue microarrays containing 88 paired CRC specimens was performed and more specific information was given in ‘Methods
  2. Key: *indicates P < 0.05. a Chi-square test. b Fisher’s exact test