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Fig. 5 | BMC Cancer

Fig. 5

From: Metalloproteases meprin-ɑ (MEP1A) is a prognostic biomarker and promotes proliferation and invasion of colorectal cancer

Fig. 5

Immunohistochemical staining in colorectal cancer and Kaplan-Meier plots with log rank test of overall survival (OS). Adjacent normal mucosa showing very weak MEP1A staining (upper left, 200×), and high staining of MEP1A (upper right, 200×) in a moderately differentiated colon tumor. On the contrary, E-cadherin showing high expression in normal mucosa (lower left, 200×) while very weak staining in poorly differentiated tumor tissue (lower right, 200×) (a). Overall survival of 88 patients in relation to MEP1A expression levels as determined by immunohistochemical staining of tissue microarrays. OS was significantly lower in patients with tumors that expressed high levels of MEP1A as compared patients with tumors that expressed low levels of MEP1A (b)

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