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Table 1 Correlation between annexin expression and the clinicopathological characteristics of patients with cervical cancer

From: Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer

Group No ANXA2 ANXA4
Mean histoscore [95 % CI] P value Mean histoscore (95 % CI) P value
 Normal 46 133 [111–156] 0.002 34 [21–46] <0.001
 Cancer 336 94 [88–101]   73 [65–81]  
Age      
 <50 year 203 95 [87–103] 0.731 79 [68–89] 0.096
 >50 year 133 93 [83–103]   65 [53–77]  
FIGO Stage      
 ≤ IIA 291 90 [83–97] 0.002 74 [66–83] 0.543
 ≥ IIB 45 121 [103–138]   67 [47–88]  
Cell type      
 SCC 256 101 [93–108] <0.001 51 [44–58] <0.001
 AD/ASC 80 73 [62–84]   145 [126–163]  
Tumor size      
 ≤4 cm 256 90 [82–97] 0.010 76 [66–85] 0.317
 >4 cm 80 109 [96–121]   66 [49–83]  
LVSI      
 Negative 202 88 [80–96] 0.019 83 [72–93] 0.005
 Positive 133 104 [93–114]   60 [48–72]  
Depth of invasion      
 <50 % 108 70 [60–80] <0.001 70 [55–84] 0.565
 ≥50 % 228 106 [98–113]   75 [65–85]  
LN metastasis      
 Negative 256 88 [81–95] 0.002 76 [66–85] 0.250
 Positive 80 113 [100–127]   65 [50–81]  
PM involvement      
 Negative 305 92 [85–98] 0.031 74 [65–82] 0.662
 Positive 31 118 [95–141]   68 [42–94]  
Resection margin      
 Negative 323 94 [87–100] 0.420 75 [66–83] 0.032
 Positive 13 111 [66–157]   43 [15–71]  
Primary Treatment      
 OP only 171 82 [73–90] <0.001 78 [66–90] 0.354
 OP + RT 70 110 [95–125]   71 [53–89]  
 OP + CCRT 90 107 [95–119]   68 [54–82]  
 Neoadjuvant 5 75 [45–105]   26 [8–59]  
  1. ANX annexin, FIGO International Federation of Gynecology and Obstetrics, SCC squamous cell carcinoma, AD adenocarcinoma, ASC adenosquamous cell carcinoma, LVSI lymphovascular space invasion, LN lymph node, PM parametrium, OP operation, RT radiotherapy, CCRT concurrent chemoradiation