EGFR gene amplification is relatively common and associates with outcome in intestinal adenocarcinoma of the stomach, gastro-oesophageal junction and distal oesophagus

Table 2 Intensity of EGFR and HER2 immunohistochemical stainings in intestinal adenocarcinomas^a (N = 220)

IHC staining intensity	EGFR, N (%)^a	HER2, N (%)^b	EGFR and HER2, N (%)^c
0/1+	148 (67.3)	189 (85.9)	131 (59.5)
2+/3+	72 (32.7)	31 (14.1)	14 (6.4)

IHC immunohistochemistry. 0, negative; 1+ low; 2+ moderate; 3+ strong
^aAccording to the most intense membranous or membranous + cytoplasmic staining
^bAccording to the most intense membranous staining
^cConcordant IHC staining intensity. In 75 tumours (34.1 %) IHC staining intensity was discordant

ISSN: 1471-2407