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Fig. 2 | BMC Cancer

Fig. 2

From: EGFR gene amplification is relatively common and associates with outcome in intestinal adenocarcinoma of the stomach, gastro-oesophageal junction and distal oesophagus

Fig. 2

The association between strong EGFR/HER2 protein expression and EGFR/HER2 gene amplification in a single intestinal-type oesophagogastric adenocarcinoma (original objective magnification 10x). All images are from the same area of the tumour. a Strong (3+) EGFR protein expression (IHC). b EGFR gene amplification (SISH). c Strong (3+) HER2 protein expression (IHC). d HER2 gene amplification (SISH). Insets show the gene amplification (original objective magnification 60x). Note that EGFR and HER2 are not amplified in the same cancer cells but in adjacent areas. IHC, immunohistochemistry; SISH, silver in situ hybridisation

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