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Table 2 Multivariate hazard ratios (HR) for overall, breast cancer-specific, disease-free, and distant disease-free survival

From: Detection of circulating tumor cells using manually performed immunocytochemistry (MICC) does not correlate with outcome in patients with early breast cancer – Results of the German SUCCESS-A- trial

  Overall survival Breast-cancer-specific survival Disease-free survival Distant-disease-free survival
HR 95 % CI p-value HR 95 % CI p-value HR 95 % CI p-value HR 95 % CI p-value
Final Model (without CTC presence):
Age 0.96 0.94 – 0.99 0.007
Tumor stage    <0.001    <0.001    0.001    0.001
 T2 vs. T1 1.43 0.92 – 2.21 0.11 1.70 1.04 – 2.78 0.03 1.21 0.86 – 1.69 0.27 1.35 0.90 – 2.03 0.15
 T3 vs. T1 1.97 0.95 – 4.08 0.07 2.78 1.29 – 5.97 0.01 1.35 0.73 – 2.50 0.35 1.22 0.56 – 2.65 0.62
 T4 vs. T1 9.33 4.01 – 21.69 <0.001 9.98 3.92 – 25.40 <0.001 5.25 2.35 – 11.73 <0.001 6.88 2.62 – 18.06 <0.001
Nodal stage    <0.001    <0.001    <0.001    <0.001
 N1 vs. N0 1.49 0.91 – 2.45 0.11 1.85 1.08 – 3.18 0.03 1.53 1.03 – 2.27 0.03 2.17 1.32 – 3.57 0.002
 N2 vs. N0 1.69 0.92 – 3.10 0.09 1.80 0.92 – 3.50 0.09 1.90 1.18 – 3.06 0.01 3.35 1.89 – 5.96 <0.001
 N3 vs. N0 6.66 3.57 – 12.42 <0.001 8.59 4.42 – 16.68 <0.001 6.65 3.98 – 11.10 <0.001 10.76 5.82 – 19.89 <0.001
Hormone receptor status
 pos vs. neg 0.31 0.20 – 0.46 <0.001 0.27 0.16 – 0.43 <0.001 0.35 0.25 – 0.49 <0.001 0.32 0.22 – 0.46 <0.001
Her2 status
 pos vs. neg 0.59 0.36 – 0.95 0.03 0.58 0.35 – 0.96 0.04 0.70 0.48 – 1.02 0.06 - - -
Grading    -    0.21    -    -
 G2 vs. G1 - - - 4.85 0.66 – 35.49 0.12 - - - - - -
 G3 vs. G1 - - - 5.71 0.78 – 41.80 0.09 - - - - - -
Menopausal status
 post vs. pre - - - - - - - - - 1.66 0.92 – 2.99 0.09
Addition of CTC presence
CTCs
 pos vs. neg 1.38 0.91 – 2.11 0.14 1.39 0.88 – 2.20 0.17 1.19 0.84 – 1.69 0.34 1.34 0.89 – 2.02 0.17
  1. Shown is the final model (Cox proportional hazards regression model, without CTC presence) after backward selection (see text), and the parameter estimates, as well as the significance of the change when CTC presence (yes/no) was added to the model. Please note that the addition of CTC presence did not significantly improve model fit for any of the four analyzed survival endpoints