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Fig. 1 | BMC Cancer

Fig. 1

From: Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer

Fig. 1

Development and analyses of the parental breast cancer cell lines and their tamoxifen-resistant variants. a Schematic representation of the four parental cell lines (MCF-7, T-47D, ZR-75-1 and BT-474) and their seven tamoxifen-resistant variants (arrows) that were developed through continuous tamoxifen-treatment. b Followed by molecular and cell biological characterization (1), drug sensitivity and resistance testing and exome-sequencing to detect point mutations (single nucleotide polymorphisms, SNP) and copy number variations (CNV) (2), the data was then integrated and the pharmacogenomic relationships visualized through network modeling (3). DT = Drug target. To reveal drug responses and genetic changes associated with tamoxifen resistance, all analyses were performed by comparing each tamoxifen-resistant cell line to its parental control cell line

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