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Table 3 Association between mammographic density/structural appearance and breast cancer in 380 screening womena

From: Mammographic density and structural features can individually and jointly contribute to breast cancer risk assessment in mammography screening: a case–control study

  Cases/controls (n) Case-ratio OR (95 % Cl)b p-value AUC (95 % Cl)b
BI-RADS      0.63 (0.57–0.69)
 D1 30/107 21.9 1 (reference) -  
 D2 31/73 29.8 1.53 (0.85–2.75) NS  
 D3 37/57 39.4 2.37 (1.32–4.25) 0.004  
 D4 23/22 51.1 3.93 (1.88–8.20) <0.001  
Tabár      0.65 (0.59–0.71)
 PI 38/96 28.4 1.81 (0.96–3.42) NS  
 PII 18/83 17.8 1 (reference) -  
 PIII 9/13 40.9 3.23 (1.20–8.75) 0.021  
 PIV 49/51 49.0 4.40 (2.31–8.38) <0.001  
 PV 7/16 30.4 1.97 (0.70–5.57) NS  
Automated texture (MTR)c      0.63 (0.57–0.69) cont.
0.63 (0.56–0.69) cat.
 Q1 19/65 22.6 1 (reference) -  
 Q2 24/65 27.0 1.27 (0.63–2.54) NS  
 Q3 21/65 24.4 1.11 (0.54–2.25) NS  
 Q4 57/64 47.1 3.04 (1.63–5.67) <0.001  
BI-RADS + MTR      0.66 (0.60–0.72)
 Q1 11/64 14.7 1 (reference) -  
 Q2 23/65 26.1 2.06 (0.93–4.57) NS  
 Q3 33/66 33.3 2.91 (1.36–6.25) 0.006  
 Q4 54/64 45.8 4.91 (2.35–10.24) <0.001  
BI-RADS + Tabár      0.67 (0.61–0.72)
 Q1 13/64 16.9 1 (reference) -  
 Q2 19/64 22.9 1.46 (0.67–3.21) NS  
 Q3 30/66 31.3 2.24 (1.07–4.67) 0.032  
 Q4 59/65 47.6 4.47 (2.24–8.94) <0.001  
Tabár + MTR      0.68 (0.62–0.73)
 Q1 13/65 16.7 1 (reference) -  
 Q2 22/65 25.3 1.69 (0.79–3.64) NS  
 Q3 24/65 27.0 1.85 (0.87–3.94) NS  
 Q4 62/64 49.2 4.84 (2.43–9.66) <0.001  
BI-RADS + MTR + Tabár      0.69 (0.63–0.74)
 Q1 12/64 15.8 1 (reference) -  
 Q2 16/66 19.5 1.29 (0.57–2.95) NS  
 Q3 28/65 30.1 2.30 (1.08–4.91) 0.032  
 Q4 65/64 50.4 5.42 (2.67–10.98) <0.001  
  1. aBI-RADS and Tabár are based on consensus scores between two readers. Regarding all three methods the maximum breast score has been used as the woman’s final score (Tabár ranked as follows: PII, PIII, PI, PV, PIV). Regarding MTR an average of CC and MLO was used as the breast score
  2. bORs and AUCs are adjusted for age. A significant difference in AUC was seen for BI-RADS + Tabár + MTR versus BI-RADS and BI-RADS + Tabár + MTR versus MTR
  3. cCut points for MTR scores are based on an equal number of controls in each group: Q1) 0–0.5047, Q2) 0.5047-0.5284, Q3) 0.5284-0.5469, Q4) 0.5469-1.00