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Table 3 Association between mammographic density/structural appearance and breast cancer in 380 screening womena

From: Mammographic density and structural features can individually and jointly contribute to breast cancer risk assessment in mammography screening: a case–control study

 

Cases/controls (n)

Case-ratio

OR (95 % Cl)b

p-value

AUC (95 % Cl)b

BI-RADS

    

0.63 (0.57–0.69)

 D1

30/107

21.9

1 (reference)

-

 

 D2

31/73

29.8

1.53 (0.85–2.75)

NS

 

 D3

37/57

39.4

2.37 (1.32–4.25)

0.004

 

 D4

23/22

51.1

3.93 (1.88–8.20)

<0.001

 

Tabár

    

0.65 (0.59–0.71)

 PI

38/96

28.4

1.81 (0.96–3.42)

NS

 

 PII

18/83

17.8

1 (reference)

-

 

 PIII

9/13

40.9

3.23 (1.20–8.75)

0.021

 

 PIV

49/51

49.0

4.40 (2.31–8.38)

<0.001

 

 PV

7/16

30.4

1.97 (0.70–5.57)

NS

 

Automated texture (MTR)c

    

0.63 (0.57–0.69) cont.

0.63 (0.56–0.69) cat.

 Q1

19/65

22.6

1 (reference)

-

 

 Q2

24/65

27.0

1.27 (0.63–2.54)

NS

 

 Q3

21/65

24.4

1.11 (0.54–2.25)

NS

 

 Q4

57/64

47.1

3.04 (1.63–5.67)

<0.001

 

BI-RADS + MTR

    

0.66 (0.60–0.72)

 Q1

11/64

14.7

1 (reference)

-

 

 Q2

23/65

26.1

2.06 (0.93–4.57)

NS

 

 Q3

33/66

33.3

2.91 (1.36–6.25)

0.006

 

 Q4

54/64

45.8

4.91 (2.35–10.24)

<0.001

 

BI-RADS + Tabár

    

0.67 (0.61–0.72)

 Q1

13/64

16.9

1 (reference)

-

 

 Q2

19/64

22.9

1.46 (0.67–3.21)

NS

 

 Q3

30/66

31.3

2.24 (1.07–4.67)

0.032

 

 Q4

59/65

47.6

4.47 (2.24–8.94)

<0.001

 

Tabár + MTR

    

0.68 (0.62–0.73)

 Q1

13/65

16.7

1 (reference)

-

 

 Q2

22/65

25.3

1.69 (0.79–3.64)

NS

 

 Q3

24/65

27.0

1.85 (0.87–3.94)

NS

 

 Q4

62/64

49.2

4.84 (2.43–9.66)

<0.001

 

BI-RADS + MTR + Tabár

    

0.69 (0.63–0.74)

 Q1

12/64

15.8

1 (reference)

-

 

 Q2

16/66

19.5

1.29 (0.57–2.95)

NS

 

 Q3

28/65

30.1

2.30 (1.08–4.91)

0.032

 

 Q4

65/64

50.4

5.42 (2.67–10.98)

<0.001

 
  1. aBI-RADS and Tabár are based on consensus scores between two readers. Regarding all three methods the maximum breast score has been used as the woman’s final score (Tabár ranked as follows: PII, PIII, PI, PV, PIV). Regarding MTR an average of CC and MLO was used as the breast score
  2. bORs and AUCs are adjusted for age. A significant difference in AUC was seen for BI-RADS + Tabár + MTR versus BI-RADS and BI-RADS + Tabár + MTR versus MTR
  3. cCut points for MTR scores are based on an equal number of controls in each group: Q1) 0–0.5047, Q2) 0.5047-0.5284, Q3) 0.5284-0.5469, Q4) 0.5469-1.00