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Table 2 Univariable analysis of factors associated with overall survival

From: Poor survival in stage IIB/C (T4N0) compared to stage IIIA (T1-2 N1, T1N2a) colon cancer persists even after adjusting for adequate lymph nodes retrieved and receipt of adjuvant chemotherapy

 

Before matching

After matching

Variable

HR

95 % CI

P-value

HR

95 % CI

P-value

Stage

 Stage IIB/C

2.15

(2.07, 2.24)

<.0001

1.70

(1.62, 1.78)

<.0001

 Stage IIIA

1.00

1.00

Age

 18–49

1.00

1.00

 50–64

1.30

(1.17, 1.45)

<.0001

1.41

(1.22, 1.63)

<.0001

 65–74

2.23

(2.02, 2.48)

<.0001

2.48

(2.16, 2.86)

<.0001

 75 and more

4.86

(4.41, 5.37)

<.0001

5.12

(4.47, 5.87)

<.0001

Race/ Ethnicity

 White

1.00

1.00

 Black

0.96

(0.91, 1.02)

0.19

1.06

(0.98, 1.14)

0.14

 American Indian, Aleutian, or Eskimo

0.90

(0.61, 1.33)

0.60

0.93

(0.58, 1.47)

0.75

 Asian or Pacific Islander

0.55

(0.47, 0.64)

<.0001

0.62

(0.50, 0.75)

<.0001

 Other

0.63

(0.46, 0.87)

0.005

0.64

(0.41, 0.99)

0.05

Facility Type

 Community cancer program

1.39

(1.31, 1.48)

<.0001

1.40

(1.30, 1.52)

<.0001

 Comprehensive community cancer center

1.21

(1.16, 1.26)

<.0001

1.24

(1.17, 1.31)

<.0001

 Academic research program

1.00

1.00

Facility Location

 New England

1.08

(0.99, 1.18)

0.10

0.94

(0.84, 1.06)

0.32

 Mid Atlantic

1.07

(0.99, 1.16)

0.07

0.98

(0.89, 1.08)

0.68

 South Atlantic

1.06

(0.99, 1.13)

0.12

1.00

(0.92, 1.09)

0.98

 East North Central

1.10

(1.03, 1.18)

0.008

1.04

(0.95, 1.14)

0.39

 East South Central

1.09

(0.998, 1.20)

0.05

1.08

(0.97, 1.21)

0.16

 West North Central

1.10

(1.005, 1.19)

0.04

1.04

(0.94, 1.16)

0.43

 West South Central

1.01

(0.92, 1.11)

0.80

0.99

(0.89, 1.11)

0.84

 Mountain

0.93

(0.83, 1.04)

0.20

0.87

(0.75, 1.01)

0.06

 Pacific

1.00

1.00

Urban/Rural Location

 Metro ≥1 million

1.00

1.00

 Metro 250 k to 1 million

1.07

(1.02, 1.12)

0.008

1.09

(1.03, 1.15)

0.004

 Urban <250 k

1.07

(1.004, 1.14)

0.04

1.06

(0.98, 1.14)

0.17

 Urban ≥ 20 k adjacent metro

1.10

(1.002, 1.21)

0.046

1.10

(0.98, 1.24)

0.09

 Urban ≥ 20 k not adjacent metro

1.04

(0.89, 1.22)

0.65

1.05

(0.87, 1.26)

0.63

 Urban <20 k adjacent metro

1.13

(1.04, 1.23)

0.006

1.06

(0.95, 1.18)

0.30

 Urban <20 k not adjacent metro

1.23

(1.10, 1.38)

0.0005

1.32

(1.15, 1.52)

0.0001

 Rural <2500 adjacent metro

1.02

(0.85, 1.24)

0.81

0.88

(0.68, 1.14)

0.33

 Rural <2500 not adjacent metro

1.12

(0.94, 1.33)

0.21

1.06

(0.85, 1.32)

0.58

Comorbidities

 0

1.00

1.00

 1

1.46

(1.40, 1.53)

<.0001

1.49

(1.42, 1.58)

<.0001

 2

2.29

(2.16, 2.42)

<.0001

2.29

(2.13, 2.46)

<.0001

Primary Site

 Cecum

1.00

1.00

 Ascending Colon

0.96

(0.91, 1.02)

0.15

1.04

(0.97, 1.11)

0.30

 Hepatic Flexure

0.97

(0.88, 1.07)

0.51

0.95

(0.84, 1.07)

0.39

 Transverse Colon

1.07

(0.997, 1.14)

0.06

0.93

(0.85, 1.02)

0.11

 Splenic Flexure

1.07

(0.96, 1.18)

0.23

0.90

(0.77, 1.04)

0.15

 Descending Colon

0.85

(0.78, 0.93)

0.0003

0.85

(0.77, 0.95)

0.003

 Sigmoid Colon

0.76

(0.72, 0.80)

<.0001

0.82

(0.77, 0.87)

<.0001

 Overlapping Lesions

1.19

(1.03, 1.38)

0.02

0.80

(0.62, 1.03)

0.08

 Not Otherwise Specified

1.14

(1.004, 1.29)

0.04

1.13

(0.95, 1.33)

0.17

Grade

 Well differentiated

1.00

1.00

 Moderately differentiated

1.09

(1.02, 1.16)

0.01

1.04

(0.96, 1.13)

0.37

 Poorly differentiated

1.39

(1.29, 1.50)

<.0001

1.11

(1.01, 1.22)

0.03

 Undifferentiated, anaplastic

1.74

(1.53, 1.97)

<.0001

1.23

(1.02, 1.48)

0.03

Surgical Margins

 No residual tumor

1.00

1.00

 With Residual tumor

1.91

(1.81, 2.02)

<.0001

1.24

(1.03, 1.49)

0.02

Readmission within 30 days of Surgery

 Not readmitted

1.00

1.00

 Readmitted

1.15

(1.08, 1.22)

<.0001

1.13

(1.05, 1.22)

0.002

Regional Lymph Nodes Examined

 0–11

1.34

(1.29, 1.39)

<.0001

1.29

(1.23, 1.35)

<.0001

 12–90

1.00

1.00

Chemotherapy

 Yes

1.00

1.00

 No

3.55

(3.41, 3.70)

<.0001

3.49

(3.32, 3.67)

<.0001