Table 1 Comparison of demographic and therapeutic characteristics of stage IIB/C and stage IIIA

No. of patients (%)

18,609 (53.2)

16,390 (46.8)

11,409 (50.0)

11,409 (50.0)

Age

<.0001

0.94

 18–49

1,678 (9.0)

1424 (8.7)

935 (8.2)

920 (8.1)

 50–64

4,628 (24.9)

5284 (32.2)

2,979 (26.1)

3,016 (26.4)

 65–74

4,368 (23.5)

4419 (27.0)

2,957 (25.9)

2,956 (25.9)

 75 and more

7,935 (42.6)

5263 (32.1)

4,538 (39.8)

4,517 (39.6)

Distance from cancer reporting facility

0.06

0.58

 <50 miles

16,909 (92.9)

15,015 (93.4)

10,630 (93.2)

10,651 (93.4)

 ≥50 miles

1,303 (7.2)

1,066 (6.6)

779 (6.8)

758 (6.6)

Race/Ethnicity

<.0001

0.93

 White

15,964 (86.5)

13,450 (82.8)

9,785 (85.8)

9,770 (85.6)

 Black

1,965 (10.6)

2,197 (13.5)

1,283 (11.3)

1,308 (11.5)

 American Indian, Aleutian, or Eskimo

53 (0.3)

36 (0.2)

27 (0.2)

31 (0.3)

 Asian or Pacific Islander

390 (2.1)

456 (2.8)

261 (2.3)

251 (2.2)

 Other

89 (0.5)

100 (0.6)

53 (0.5)

49 (0.4)

Facility Type

0.02

0.90

 Community cancer program

2,715 (14.6)

2,239 (13.7)

1,565 (13.7)

1,588 (13.9)

 Comprehensive community cancer center

11,044 (59.4)

9,700 (59.2)

6,815 (59.7)

6,804 (59.6)

 Academic research program

4,825 (25.9)

4,432 (27.0)

3,029 (26.6)

3,017 (26.4)

 Other specified types of cancer program

25 (0.1)

19 (0.1)

Facility Location

<.0001

0.99

 New England

1,335 (7.2)

886 (5.4)

678 (5.9)

692 (6.1)

 Mid Atlantic

2,971 (16.0)

2,402 (14.7)

1,814 (15.9)

1,809 (15.9)

 South Atlantic

3,835 (20.6)

3,715 (22.7)

2,352 (20.6)

2,391 (21.0)

 East North Central

3,580 (19.2)

3,127 (19.1)

2,174 (19.1)

2,201 (19.3)

 East South Central

1,162 (6.2)

1,186 (7.2)

788 (6.9)

786 (6.9)

 West North Central

1,555 (8.4)

1,333 (8.1)

1,035 (9.1)

1,002 (8.8)

 West South Central

1,487 (8.0)

1,391 (8.5)

942 (8.3)

938 (8.2)

 Mountain

779 (4.2)

678 (4.1)

440 (3.9)

438 (3.8)

 Pacific

1,905 (10.2)

1,672 (10.2)

1,186 (10.4)

1,152 (10.1)

Urban/Rural Location

0.05

0.96

 Metro ≥1 million

9,488 (53.0)

8,380 (53.1)

6,039 (52.9)

6,028 (52.8)

 Metro 250 k to 1 million

3,863 (21.6)

3,556 (22.5)

2,539 (22.3)

2,554 (22.4)

 Urban <250 k

1,766 (9.9)

1,516 (9.6)

1,104 (9.7)

1,112 (9.8)

 Urban ≥ 20 k adjacent metro

731 (4.1)

657 (4.2)

460 (4.0)

476 (4.2)

 Urban ≥ 20 k not adjacent metro

262 (1.5)

221 (1.4)

182 (1.6)

175 (1.5)

 Urban <20 k adjacent metro

957 (5.4)

751 (4.8)

577 (5.1)

572 (5.0)

 Urban <20 k not adjacent metro

454 (2.5)

387 (2.5)

286 (2.5)

258 (2.3)

 Rural <2500 adjacent metro

164 (0.9)

169 (1.1)

108 (1.0)

109 (1.0)

 Rural <2500 not adjacent metro

212 (1.2)

154 (1.0)

114 (1.0)

125 (1.1)

Comorbidities

<.0001

0.61

 0

12,872 (69.2)

11,665 (71.2)

7,905 (69.3)

7,962 (69.8)

 1

4,185 (22.5)

3,537 (21.6)

2,576 (22.6)

2,513 (22.0)

 2

1,552 (8.3)

1,188 (7.3)

928 (8.1)

934 (8.2)

Primary Site

<.0001

0.99

 Cecum

4,917 (26.4)

3,941 (24.1)

3,077 (27.0)

3,077 (27.0)

 Ascending Colon

2,876 (15.5)

3,140 (19.2)

1,969 (17.3)

1,992 (17.5)

 Hepatic Flexure

748 (4.0)

608 (3.7)

473 (4.2)

461 (4.0)

 Transverse Colon

2,061 (11.1)

1,154 (7.0)

1,031 (9.0)

991 (8.7)

 Splenic Flexure

786 (4.2)

366 (2.2)

312 (2.7)

327 (2.9)

 Descending Colon

1,161 (6.2)

960 (5.9)

705 (6.2)

706 (6.2)

 Sigmoid Colon

5,324 (28.6)

5,756 (35.1)

3,524 (30.9)

3,535 (31.0)

 Overlapping Lesions

369 (2.0)

140 (0.9)

120 (1.1)

121 (1.1)

 Not Otherwise Specified

367 (2.0)

325 (2.0)

198 (1.7)

199 (1.7)

Grade

<.0001

0.87

 Well differentiated

1,506 (8.4)

1,779 (11.4)

1,087 (9.5)

1,084 (9.5)

 Moderately differentiated

11,868 (66.0)

11,226 (71.9)

8,007 (70.2)

8,049 (70.6)

 Poorly differentiated

4,004 (22.3)

2,381 (15.3)

2,084 (18.3)

2,059 (18.1)

 Undifferentiated, anaplastic

611 (3.4)

230 (1.5)

231 (2.0)

217 (1.9)

Surgical Margins

<.0001

0.87

 No residual tumor

14992 (82.6)

16,012 (98.8)

11,243 (98.6)

11,246 (98.6)

 With Residual tumor

3156 (17.4)

190 (1.2)

166 (1.5)

163 (1.4)

Regional Lymph Nodes Examined

<.0001

<.0001

 0–11

4,399 (23.8)

4,867 (29.9)

2,422 (21.3)

3,298 (29.0)

 12–90

14,101 (76.2)

11,434 (70.1)

8,944 (78.7)

8,078 (71.0)

Chemotherapy

<.0001

<.0001

 None

10,423 (58.7)

4,807 (30.5)

6,362 (58.4)

3,659 (33.3)

 Yes

7,335 (41.3)

10,975 (69.5)

4,525 (41.6)

7,327 (66.7)