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Table 2 Hazard ratios and 95 % confidence intervals for CRC-specific mortality by pre-diagnostic BMI

From: Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study

  BMI (kg/m2)  
  18.5–24.9 25–29.9 ≥30 Per 5 kg/m2 Ptrenda
MEN
 CRC, n = 1336
  Person-years 3320 3563 710   
  Number of CRC-related deaths 198 254 55   
  HR (95 % CI)b 1 (Ref) 0.98 (0.81, 1.18) 1.01 (0.74, 1.37) 0.99 (0.86, 1.14) 0.87
 Colon cancer, n = 847
  Person-years 1936 2144 433   
  Number of CRC-related deaths 125 158 39   
  HR (95 % CI)b 1 (Ref) 1.02 (0.80, 1.30) 1.26 (0.87, 1.83) 1.07 (0.90, 1.28) 0.43
 Proximal colon cancer, n = 443
  Person-years 1072 1058 160   
  Number of CRC-related deaths 63 80 19   
  HR (95 % CI)b 1 (Ref) 1.17 (0.82, 1.66) 1.85 (1.08, 3.16) 1.19 (0.93, 1.54) 0.17
 Distal colon cancer, n = 369
  Person-years 848 996 272   
  Number of CRC-related deaths 53 65 18   
  HR (95 % CI)b 1 (Ref) 0.91 (0.63, 1.33) 0.91 (0.52, 1.59) 0.98 (0.75, 1.30) 0.91
 Rectal cancer, n = 478
  Person-years 1374 1371 273   
  Number of CRC-related deaths 73 94 16   
  HR (95 % CI)b 1 (Ref) 0.99 (0.71, 1.37) 0.75 (0.43, 1.33) 0.93 (0.73, 1.17) 0.52
WOMEN
 CRC, n = 1180
  Person-years 3793 2175 1064   
  Number of CRC-related deaths 220 138 74   
  HR (95 % CI)b 1 (Ref) 1.07 (0.85, 1.33) 1.31 (0.99, 1.72) 1.04 (0.93, 1.17) 0.51
 Colon cancer, n = 808
  Person-years 2469 1386 760   
  Number of CRC-related deaths 153 90 50   
  HR (95 % CI)b 1 (Ref) 0.97 (0.74, 1.27) 1.25 (0.89, 1.74) 1.02 (0.89, 1.18) 0.75
 Proximal colon cancer, n = 493
  Person-years 1279 876 372   
  Number of CRC-related deaths 93 53 29   
  HR (95 % CI)b 1 (Ref) 0.89 (0.63, 1.28) 1.23 (0.80, 1.91) 1.02 (0.84, 1.24) 0.82
 Distal colon cancer, n = 294
  Person-years 1160 467 369   
  Number of CRC-related deaths 54 34 17   
  HR (95 % CI)b 1 (Ref) 1.33 (0.84, 2.11) 1.18 (0.64, 2.16) 1.06 (0.83, 1.35) 0.65
 Rectal cancer, n = 367
  Person-years 1271 788 283   
  Number of CRC-related deaths 67 47 24   
  HR (95 % CI)b 1 (Ref) 1.42 (0.95, 2.13) 1.93 (1.13, 3.30) 1.18 (0.96, 1.47) 0.12
  1. a Wald P-value for BMI as continuous variable
  2. b Stratified Cox model (year of diagnosis: < 1990, 1990–1994, 1995–1999, 2000–2004, ≥ 2005). Adjustment for age at diagnosis, stage of disease at diagnosis (localized, regional, or distant), smoking (never, former, or current), physical activity level (sedentary, moderately active, or active), education (≤ 9, 10-12, or ≥ 13 years)