Skip to main content

Table 2 Hazard ratios and 95 % confidence intervals for CRC-specific mortality by pre-diagnostic BMI

From: Pre-diagnostic body mass index and weight change in relation to colorectal cancer survival among incident cases from a population-based cohort study

 

BMI (kg/m2)

 
 

18.5–24.9

25–29.9

≥30

Per 5 kg/m2

Ptrenda

MEN

 CRC, n = 1336

  Person-years

3320

3563

710

  

  Number of CRC-related deaths

198

254

55

  

  HR (95 % CI)b

1 (Ref)

0.98 (0.81, 1.18)

1.01 (0.74, 1.37)

0.99 (0.86, 1.14)

0.87

 Colon cancer, n = 847

  Person-years

1936

2144

433

  

  Number of CRC-related deaths

125

158

39

  

  HR (95 % CI)b

1 (Ref)

1.02 (0.80, 1.30)

1.26 (0.87, 1.83)

1.07 (0.90, 1.28)

0.43

 Proximal colon cancer, n = 443

  Person-years

1072

1058

160

  

  Number of CRC-related deaths

63

80

19

  

  HR (95 % CI)b

1 (Ref)

1.17 (0.82, 1.66)

1.85 (1.08, 3.16)

1.19 (0.93, 1.54)

0.17

 Distal colon cancer, n = 369

  Person-years

848

996

272

  

  Number of CRC-related deaths

53

65

18

  

  HR (95 % CI)b

1 (Ref)

0.91 (0.63, 1.33)

0.91 (0.52, 1.59)

0.98 (0.75, 1.30)

0.91

 Rectal cancer, n = 478

  Person-years

1374

1371

273

  

  Number of CRC-related deaths

73

94

16

  

  HR (95 % CI)b

1 (Ref)

0.99 (0.71, 1.37)

0.75 (0.43, 1.33)

0.93 (0.73, 1.17)

0.52

WOMEN

 CRC, n = 1180

  Person-years

3793

2175

1064

  

  Number of CRC-related deaths

220

138

74

  

  HR (95 % CI)b

1 (Ref)

1.07 (0.85, 1.33)

1.31 (0.99, 1.72)

1.04 (0.93, 1.17)

0.51

 Colon cancer, n = 808

  Person-years

2469

1386

760

  

  Number of CRC-related deaths

153

90

50

  

  HR (95 % CI)b

1 (Ref)

0.97 (0.74, 1.27)

1.25 (0.89, 1.74)

1.02 (0.89, 1.18)

0.75

 Proximal colon cancer, n = 493

  Person-years

1279

876

372

  

  Number of CRC-related deaths

93

53

29

  

  HR (95 % CI)b

1 (Ref)

0.89 (0.63, 1.28)

1.23 (0.80, 1.91)

1.02 (0.84, 1.24)

0.82

 Distal colon cancer, n = 294

  Person-years

1160

467

369

  

  Number of CRC-related deaths

54

34

17

  

  HR (95 % CI)b

1 (Ref)

1.33 (0.84, 2.11)

1.18 (0.64, 2.16)

1.06 (0.83, 1.35)

0.65

 Rectal cancer, n = 367

  Person-years

1271

788

283

  

  Number of CRC-related deaths

67

47

24

  

  HR (95 % CI)b

1 (Ref)

1.42 (0.95, 2.13)

1.93 (1.13, 3.30)

1.18 (0.96, 1.47)

0.12

  1. a Wald P-value for BMI as continuous variable
  2. b Stratified Cox model (year of diagnosis: < 1990, 1990–1994, 1995–1999, 2000–2004, ≥ 2005). Adjustment for age at diagnosis, stage of disease at diagnosis (localized, regional, or distant), smoking (never, former, or current), physical activity level (sedentary, moderately active, or active), education (≤ 9, 10-12, or ≥ 13 years)