Skip to main content

Table 3 Cox regression analyses for progression-free survival and overall survival in patients without liver metastasis

From: Eribulin-induced liver dysfunction as a prognostic indicator of survival of metastatic breast cancer patients: a retrospective study

  

Univariate

Multivariate

  

Hazard ratio

(95 % CI)

P-value

Hazard ratio

(95 % CI)

P-value

Progression-free survival

EILD

Yes

3.35

 

0.0029

3.42

 

0.0079

 

No

 

1.51–7.44

  

1.38–8.47

 

Age

5656

0.64

 

0.11

0.67

 

0.20

 

>56

 

0.38–1.10

  

0.36–1.24

 

PS

0

0.84

 

0.58

0.68

 

0.24

 

1,2

 

0.46–1.55

  

0.36–1.30

 

Comorbid disease

Yes

1.59

 

0.15

1.47

 

0.32

 

No

 

0.85–2.99

  

0.69–3.15

 

DFI

2.82.8

1.81

 

0.035

1.79

 

0.08

 

>2.8

 

1.04–3.15

  

0.93–3.45

 

BMI

>25

1.84

 

0.073

0.86

 

0.71

 

2525

 

0.95–3.57

  

0.38–1.93

 

HR (ER/PgR) status

Positive

1.23

 

0.46

1.12

 

0.73

 

Negative

 

0.71–2.13

  

0.58–2.15

 

HER2 status

Negative

1.69

 

0.14

2.14

 

0.054

 

Positive

 

0.84–3.39

  

0.99–4.66

 

Overall survival

EILD

Yes

3.93

 

0.063

3.42

 

0.13

 

No

 

0.93–16.6

  

0.71–16.44

 

Age

5656

0.81

 

0.59

0.89

 

0.78

 

>56

 

0.38–1.73

  

0.38–2.09

 

PS

0

1.73

 

0.20

1.51

 

0.36

 

1,2

 

0.75–4.02

  

0.63–3.63

 

Comorbid disease

Yes

1.14

 

0.76

1.17

 

0.76

 

No

 

0.48–2.71

  

0.44–3.09

 

DFI

2.82.8

2.52

 

0.037

1.95

 

0.19

 

>2.8

 

1.06–5.98

  

0.73–5.25

 

BMI

>25

1.47

 

0.42

0.87

 

0.79

 

2525

 

0.59–3.62

  

0.32–2.40

 

HR (ER/PgR) status

Positive

1.54

 

0.28

0.97

 

0.95

 

Negative

 

0.71–3.34

  

0.42–2.28

 

HER2 status

Negative

2.49

 

0.057

2.20

 

0.13

 

Positive

 

0.97–6.39

  

0.79–3.09

 
  1. Abbreviation: 95 % CI 95 % confidence interval, EILD eribulin-induced liver dysfunction, PS performance status, DFI disease free interval, BMI body mass index, HR hormone receptor, ER estrogen receptor, PgR progesterone receptor, HER2 human epidermal growth factor receptor 2