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Table 3 Cox regression analyses for progression-free survival and overall survival in patients without liver metastasis

From: Eribulin-induced liver dysfunction as a prognostic indicator of survival of metastatic breast cancer patients: a retrospective study

   Univariate Multivariate
   Hazard ratio (95 % CI) P-value Hazard ratio (95 % CI) P-value
Progression-free survival
EILD Yes 3.35   0.0029 3.42   0.0079
  No   1.51–7.44    1.38–8.47  
Age ≦56≦56 0.64   0.11 0.67   0.20
  >56   0.38–1.10    0.36–1.24  
PS 0 0.84   0.58 0.68   0.24
  1,2   0.46–1.55    0.36–1.30  
Comorbid disease Yes 1.59   0.15 1.47   0.32
  No   0.85–2.99    0.69–3.15  
DFI ≦2.8≦2.8 1.81   0.035 1.79   0.08
  >2.8   1.04–3.15    0.93–3.45  
BMI >25 1.84   0.073 0.86   0.71
  ≦25≦25   0.95–3.57    0.38–1.93  
HR (ER/PgR) status Positive 1.23   0.46 1.12   0.73
  Negative   0.71–2.13    0.58–2.15  
HER2 status Negative 1.69   0.14 2.14   0.054
  Positive   0.84–3.39    0.99–4.66  
Overall survival
EILD Yes 3.93   0.063 3.42   0.13
  No   0.93–16.6    0.71–16.44  
Age ≦56≦56 0.81   0.59 0.89   0.78
  >56   0.38–1.73    0.38–2.09  
PS 0 1.73   0.20 1.51   0.36
  1,2   0.75–4.02    0.63–3.63  
Comorbid disease Yes 1.14   0.76 1.17   0.76
  No   0.48–2.71    0.44–3.09  
DFI ≦2.8≦2.8 2.52   0.037 1.95   0.19
  >2.8   1.06–5.98    0.73–5.25  
BMI >25 1.47   0.42 0.87   0.79
  ≦25≦25   0.59–3.62    0.32–2.40  
HR (ER/PgR) status Positive 1.54   0.28 0.97   0.95
  Negative   0.71–3.34    0.42–2.28  
HER2 status Negative 2.49   0.057 2.20   0.13
  Positive   0.97–6.39    0.79–3.09  
  1. Abbreviation: 95 % CI 95 % confidence interval, EILD eribulin-induced liver dysfunction, PS performance status, DFI disease free interval, BMI body mass index, HR hormone receptor, ER estrogen receptor, PgR progesterone receptor, HER2 human epidermal growth factor receptor 2
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