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Table 1 Published Randomised Controlled Trials of AWBRT as of 2015

From: Debate: adjuvant whole brain radiotherapy or not? More data is the wiser choice

Study Year of Publication Did trial complete?

Accrual Total /years

Histologies RT dose (Total Gray/#)

No of BMs

Median Overall Survival of all cohort (Months)

Did AWBRT increase intracranial control?

Did AWBRT decrease neurological death?

Adequate NCF Testing

Patchell 1998 [21] Complete

96/8

All 60 % lung 50.4/28

Single

11

Yes

Yes

No

Aoyama 2007 [11, 12] Complete

132/4

All 65 % lung 30/12

1–4

8

Yes

No difference

No

Chang 2009 [14] Incomplete

58/6

All 55 % lung 30/10

1–3

9.2

Yes

No difference

Yes

Roos 2011 [22] Incomplete

19/3

All 30/10

Single

NA

NA

NA

No

Kocher 2011 [23] Complete

359/12

All 50 % lung 30/10

1–3

10.9

Yes

Yes

No