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Table 1 Published Randomised Controlled Trials of AWBRT as of 2015

From: Debate: adjuvant whole brain radiotherapy or not? More data is the wiser choice

Study Year of Publication Did trial complete? Accrual Total /years Histologies RT dose (Total Gray/#) No of BMs Median Overall Survival of all cohort (Months) Did AWBRT increase intracranial control? Did AWBRT decrease neurological death? Adequate NCF Testing
Patchell 1998 [21] Complete 96/8 All 60 % lung 50.4/28 Single 11 Yes Yes No
Aoyama 2007 [11, 12] Complete 132/4 All 65 % lung 30/12 1–4 8 Yes No difference No
Chang 2009 [14] Incomplete 58/6 All 55 % lung 30/10 1–3 9.2 Yes No difference Yes
Roos 2011 [22] Incomplete 19/3 All 30/10 Single NA NA NA No
Kocher 2011 [23] Complete 359/12 All 50 % lung 30/10 1–3 10.9 Yes Yes No